NCT00015028已完成2 期
CS1008A Efficacy/Safety Trial of Buprenorphine/Naloxone
适应症
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 试验地点
- 2
- 主要终点
- HIV risk behaviors
研究概览
简要总结
The purpose of this study is to determine the efficacy and safety of a buprenorphine/naloxone sublingual tablet formulation as an office-based therapy for opiate-dependence treatment. The developmental objective for this combination product is an expansion of therapeutic options for the treatment of opiate dependence.
详细描述
This multicenter pivotal clinical trial was comprised of two phases. The first phase, which was four weeks in length, was double-blind placebo controlled and was primarily used to evaluate the efficacy of buprenorphine/naloxone. The second phase, lasting 48 weeks, was primarily conducted to determine the safety of buprenorphine/naloxone.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
入排标准
- 年龄范围
- 23 Years 至 59 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •DSM-IV (Diagnostic and Statistical Manual of the American Psychiatric Association) diagnosis of current opiate dependence.
- •Individuals seeking opiate-substitution pharmacotherapy for opiate dependence.
- •Males and non-pregnant, non-nursing females, 18 to 59 years of age (inclusive).
- •Individuals able to give informed consent and willing to comply with all study procedures (e.g., providing of urine samples under observation, completing questionnaires).
排除标准
- •Any acute or chronic medical condition that would make participation in the study medically hazardous (e.g., acute hepatitis, unstable cardiovascular, hepatic, or renal disease, unstable diabetes, symptomatic AIDS; not HIV-seropositivity alone).
- •Aspartate or alanine aminotransferase (AST, ALT) levels greater than three times the upper limit of normal.
- •Individuals currently taking systemic anti-retroviral or anti-fungal therapy.
- •Current dependence (by DSM-IV criteria) on any psychoactive substance other than opiates, caffeine, or nicotine.
- •Current, primary, Axis I psychiatric diagnosis other than opiate, caffeine, or nicotine dependence.
- •Females of childbearing potential who do not agree to use a medically acceptable method of birth control. Acceptable methods include
- •oral contraceptive,
- •barrier (diaphragm or condom) - a spermicide is not required due to the possibility of local irritation and allergic type reactions, but are recommended for use,
- •levonorgestrel implant,
- •intrauterine progesterone contraceptive system,
- •medroxyprogesterone acetate contraceptive injection, or
- •complete abstinence.
- •Enrollment in an opiate-substitution (i.e., methadone, levo-alpha-acetylmethadol) treatment program within 45 days of enrolling in the present study.
- •Individuals having taken (licitly or illicitly) LAAM, methadone, or naltrexone within days of enrolling in the present study.
- •Individuals having taken buprenorphine, other than as an analgesic, within 365 days of enrolling in the present study.
- •Participation in an investigational drug or device study within 45 days of enrolling in the present study.
- •Anyone, who in the opinion of site principal investigator, would not be expected to complete the first phase of the study protocol (e.g., due to pending incarceration or probable relocation from the clinic area).
结局指标
主要结局
HIV risk behaviors
Craving
Medical evaluation
Drug use
Adverse events
次要结局
未报告次要终点
研究者
研究点 (2)
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