Ventilatory Patterns During Cardiopulmonary Bypass In Pediatric Cardiac Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 68
- 试验地点
- 1
- 主要终点
- Change from Baseline Computerized tomography chest (CT chest) within 7 days postoperative
研究概览
简要总结
The lung is at risk for ischemic insults during total cardiopulmonary bypass because lung perfusion is maintained solely by the bronchial arterial system
详细描述
The study will be performed in the pediatric cardiothoracic unit, pediatric Assiut University Hospital. After obtaining approval from the local ethics committee and written informed parents consent 60 patients will be included in this study according to the following criteria:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 2 Years 至 10 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Elective cardiac surgery
- •Ventricular septal defect (VSD).
- •Atrial septal defect (ASD)
排除标准
- •Cyanotic heart disease.
- •Patients with preoperative chest problems.
- •Patients with known renal or hepatic dysfunctions.
- •Planned off-pump cardiac surgery.
- •Emergency cardiac surgery.
研究组 & 干预措施
Group A
This group will include patients with low flow of mixed oxygen / air (1:1L) during the period of cardiopulmonary bypass
干预措施: cardiopulmonary bypass (Procedure)
Group B
This group will receive low rate (4\min) with low tidal volume ( 2ml/kg ) during the period of cardiopulmonary bypass.
干预措施: cardiopulmonary bypass (Procedure)
结局指标
主要结局
Change from Baseline Computerized tomography chest (CT chest) within 7 days postoperative
时间窗: preoperative and within the first 7 days postoperative
次要结局
- Arterial blood gases(Within the first 7 days postoperative)
- Mechanical ventilation(Within the first 7 days postoperative)
- Intensive care unit stay(Within the first 7 days postoperative)
- Intubation time(Within the first 7 days postoperative)
研究者
Sayed Kaoud Abd-Elshafy
Associate profossor of anesthesiology and critical care
Assiut University