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临床试验/NCT05084547
NCT05084547已完成不适用

A Comparison of Upper Extremity Exercise Capacity and Activities of Daily Living Between Subjects With Bronchiectasis and Healthy Controls

Hacettepe University1 个研究点 分布在 1 个国家目标入组 48 人开始时间: 2020年1月22日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
48
试验地点
1
主要终点
Pulmonary function test - Forced vital capacity

研究概览

简要总结

Bronchiectasis is a chronic lung disease characterized by permanent dilatation and destruction, resulting from the destruction of elastic tissue and muscular components in the bronchial walls, due to infection or inflammation. The exercise tolerance, physical activity level, respiratory and peripheral muscle strength of patients with bronchiectasis are lower than those of healthy individuals. The decrease in exercise tolerance occurs while performing upper extremity activities as well as lower extremity tasks. Many studies have reported that upper extremity exercise capacity is reduced in chronic obstructive pulmonary disease (COPD), a disease similar to bronchiectasis, and that patients often experience significant dyspnea and fatigue during upper extremity tasks that are important for daily life. The mechanisms causing this situation may be neuromechanical dysfunction of the respiratory muscles (diaphragm and accessory respiratory muscles) (thoracoabdominal asynchrony) and changes in lung volume in activities involving the upper extremities. The disturbances in ventilatory mechanics in patients with COPD cause upper extremity exercise to be terminated at low workloads compared to healthy individuals. Upper extremity exercise has been defined as part of pulmonary rehabilitation. The determination of upper extremity exercise capacity may play a predictive role in maintaining and improving upper extremity and daily life activity level in patients with chronic lung disease.

Six-minute Pegboard and Ring test (6PBRT) is used to evaluate extremity exercise capacity and upper extremity function and endurance. The 6PBRT score and upper extremity daily living activities show a clear relationship in patients with COPD, and it can be used to determine and improve the performance of daily living activities in pulmonary rehabilitation programs. Glittre Activities of Daily Living (Glittre ADL test) covers activities that are necessary for daily living and commonly used activities. The Glittre ADL test produces similar cardiorespiratory responses when compared with the six-minute walk test. In this study, unsupported upper extremity exercise capacity and upper extremity function/endurance and the performance of daily living activities will be compared in participants with bronchiectasis and compared with healthy individuals.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Diagnosed with bronchiectasis and being clinically stable,
  • Being 18 years old or older,
  • Being able and willing to complete the informed consent process.
  • Exclusion criteria:
  • Individuals with bronchiectasis whose clinical condition is unstable,
  • Individuals with bronchiectasis who have severe neuromuscular, musculoskeletal, and rheumatological problems,
  • Being unable to cooperate,
  • Not being willing to participate in the study
  • The healthy controls will be composed of individuals who volunteered for the study without any known disease. Healthy individuals who did not volunteer to participate in the study will not be included.

排除标准

  • 未提供

结局指标

主要结局

Pulmonary function test - Forced vital capacity

时间窗: 1st day

Pulmonary function test using a spirometer will be performed. Forced vital capacity will be recorded.

Pulmonary function test - Forced mid-expiratory flow (FEF25-75)

时间窗: 1st day

Pulmonary function test using a spirometer will be performed. Forced mid-expiratory flow (FEF25-75) will be recorded.

Pulmonary function test - Forced expiratory volume in one second

时间窗: 1st day

Pulmonary function test using a spirometer will be performed. Forced expiratory volume in one second will be recorded.

Glittre Activities of Daily Living Test

时间窗: 1st day

The test covers activities that are necessary for daily living and commonly used activities that are known to be difficult for patients with COPD.

Unsupported upper extremity exercise capacity

时间窗: 1st day

Upper extremity exercise capacity will be evaluated using 6PBRT. During the test, the patient is asked to sit in front of a pegboard and move as many rings as possible from the two lower holes to the two upper holes, using both hands simultaneously, for six minutes. The number of rings carried during the six minutes constitutes the final score. Heart rate and oxygen saturation with pulse oximetry before and after the test, dyspnea, arm and general fatigue will be assessed.

Pulmonary function test - Forced expiratory volume in one second/Forced vital capacity

时间窗: 1st day

Pulmonary function test using a spirometer will be performed. Forced expiratory volume in one second/Forced vital capacity in one second will be recorded.

Pulmonary function test - Peak expiratory flow

时间窗: 1st day

Pulmonary function test using a spirometer will be performed. Peak expiratory flow will be recorded.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Aslihan Cakmak

Research Assistant

Hacettepe University

研究点 (1)

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