Combination Effect of Nefopam With Propacetamol for Postoperative Pain After Thyroidectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- VAS score on wound site and posterior neck
研究概览
简要总结
Patients undergoing thyroidectomy are suffering not only surgical wound pain but posterior neck pain because of neck extension position during the surgery. However, there has been little attention of posterior neck pain. Nefopam and Propacetamol have different pharmacodynamics and been used for postoperative pain control in thyroidectomy patients. The aim of this study is evaluation of combination effect of Nefopam and Propacetamol for acute wound pain, posterior neck pain and chronic pain after thyroidectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient who undergone open thyroidectomy
- •20~70 years old
- •ASA I~III
排除标准
- •hypersensitivity on Nefopam and Propacetamol
- •Liver failure, chronic alcohol addiction
- •severe hemolytic anemia, chronic nutrition deficiency
- •history of seizure
- •MI, MAO inhibitor
- •pregnant, breast-feeding
- •foreigners
研究组 & 干预措施
nefopam group
干预措施: Nefopam (Drug)
propacetamol group
干预措施: Propacetamol (Drug)
nefopam and propacetamol group
干预措施: Nefopam (Drug)
nefopam and propacetamol group
干预措施: Propacetamol (Drug)
结局指标
主要结局
VAS score on wound site and posterior neck
时间窗: one hour after the surgery
Patients' subject pain score through VAS on the surgery wound site and posterior neck.
次要结局
- Postoperative nausea and vomiting(for postop. 24hrs.)
- Patient satisfaction(for postop. 24hrs.)
- Additional pain rescue drug(for postop. 24hrs.)
- Chronic pain and neurogenic pain(three month after the surgery.)
- acute VAS on wound site and posterior neck(postop. 24hrs.)