Effect of Herbal Formulation on Karika Syrup on Thrombocytes Count
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 入组人数
- 72
- 试验地点
- 1
- 主要终点
- EFFECT OF HERBAL FORMULATION KARIKA SYRUP ON THROMBOCYTE COUNT
研究概览
简要总结
Effect of Herbal Formulation Karika Syrup on Thrombocyte Count.
详细描述
In this study, we will evaluate the effect of Herbal Formulation Karika (composed of Carica papaya leaf extract and Tinosporacordifolia) on Complete Blood Count, specifically on Platelet Count. Low Platelet Count is highly observant during multiple diseases namely dengue, malaria, typhoid, chikungunya, viral infections, and other Diseases.
The proposed study is a randomized, open, prospective, multicenter clinical trial. Extracts found in Karika syrup are beneficial in escalating platelet count, and also have anti-inflammatory and antipyretic activity. The therapeutic indication of Karika is proven through this clinical study in patients with low platelet count associated with dengue, typhoid, malaria, viral fever, and chikungunya fever.
Dengue is a tropical disease caused by the RNA virus which resides in mosquitoes. Symptoms include high-grade fever, visual disturbances, pain in the eyes and head, nausea, vomiting, musculoskeletal pain, stiffness of joints, mild to moderate and severe bleeding, and sometimes puerperal rash appearing on the skin due to a deficiency of thrombocytes.
The Chikungunya virus is spread by the bite of an infected mosquito. Typhoid is caused by Salmonella typhi a bacterium. Typhoid fever symptoms are seen widely in the human body that may observe from relatively minor cases of diarrhea with low-grade fever to high-grade fever and profound diarrhea with involvement of multiple systems.1
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 14 Years 至 60 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Inclusion Criteria:
- •Female and Male patients of age 14 to 60 years.
- •Patient suffering from complaints of Weakness, Fatigue, Puerperal Rashes, Shortness of Breath, Low Hemoglobin, and History of Fever on & off, Epistaxis.18
- •Patients from Karachi and Kapri Mori(Labors, Employed, Multigravida females, Housewives, Domestic helpers, Working women, School, College, and University Students).
- •All socioeconomic classes are included in the study.
- •Patients having a history of Covid-19, Viral fever, Typhoid, and other illnesses in which there has been a low platelet count.2
排除标准
- •Exclusion Criteria:
- •Pregnant females are excluded.17
- •Patients with co-morbidities like uncontrolled hypertension and liver disorder are excluded.4,5,6
- •Patient having known drug reaction from any content of formulation is excluded.7
- •Patients suffering from serious illnesses like encephalitis, coma, meningitis, or head injury that make them bedridden or hospitalized are excluded.4,6
研究组 & 干预措施
Karika Syrup
Karika syrup has been used to treat thrombocytopenia
干预措施: Karika Syrup (Drug)
结局指标
主要结局
EFFECT OF HERBAL FORMULATION KARIKA SYRUP ON THROMBOCYTE COUNT
时间窗: 3 years
This study is designed to check or confirm the Karika syrup efficacy for increasing the platelet count, its anti-inflammatory and anti-pyretic actions. This medicinal use of Karika will be confirmed through clinical studies in patients with low platelet count associated with dengue, typhoid, malaria, viral fever\& chikungunya fever.9 It is based on the interpretations as generated from CBC by analyzing it on SPSS. 10 It is research-based open, randomized clinical trial on 72 subjects Multi-centered: Karachi (Kalaboard, Jafar-e-tyyar) and Interior Sindh (Kapri Mori).
次要结局
未报告次要终点
研究者
Dr. Hafiz Muhammad Asif
Chairperson Department of Eastern Medicine, Jinnah University
Shifa Ul Mulk Memorial Hospital