Cardiovascular Longitudinal the Avon Longitudinal Study of Parents and Children (ALSPAC) Research Investigations Following Hypertensive Pregnancy in Young Adulthood
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Cardiac right ventricular mass
研究概览
简要总结
The purpose of this study is to understand more about why young people who were born to a hypertensive pregnancy may have increased risk of high blood pressure and are often at increased risk of heart and blood vessel disease later in life.
详细描述
Women who develop blood pressure problems during pregnancy are more likely to have high blood pressure (hypertension) in later life as well as heart attacks or strokes. The children born to the pregnancy also tend to have higher blood pressure and are often at increased risk of heart and blood vessel disease later in life. Previous work has shown that children born to pregnancies where the mother has high blood pressure have changes in their blood vessels, heart and brain that can be measured long before they develop high blood pressure or other clinical symptoms. By understanding the pattern of changes cross multiple parts of the body, over a lifetime, the investigators can identify how advanced the underlying disease is for an individual and how their disease is likely to develop over the next few years.
The aim of this study is to understand the heart and blood vessel changes of people born to a hypertensive pregnancy once they are in their 20s and 30s. The investigators then hope to use this information to develop new ways to prevent early onset heart and blood vessel disease in these people.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 30 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Participant is willing and able to give informed consent for participation in the study
- •Male or female, aged 30 to 40 years at time of enrolment
- •Participant previously took part in the ALSPAC study
- •Able (in the investigator's opinion) and willing to comply with all study requirements
- •Adequate understanding of verbal and written English
排除标准
- •Pregnant or lactating when they are due to attend for study visit 1
- •Less than six months postpartum
- •Planning to donate blood within two weeks prior to study visit 1
- •Any significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study
- •Evidence of congenital heart disease or significant chronic disease relevant to cardiovascular or metabolic status
- •For exclusion of MRI component only:
- •Unsuitable for MRI based on participant screening; the participant may still be included in other parts of the study
结局指标
主要结局
Cardiac right ventricular mass
时间窗: 30-40 years of old
Magnetic resonance imaging (MRI) assessment of cardiac right ventricular mass indexed to body surface area (in g and g/m\^2)
次要结局
- Cardiac right ventricular end-diastolic volume(30-40 years of old)
- Cardiac left ventricular systolic function(30-40 years of old)
- Renal function(30-40 years of old)
- Carbon dioxide exchange kinetics across sub-maximal and peak exercise(30-40 years of old)
- Objective measure of physical activity(30-40 years of old)
- Insulin resistance index (HOMA-IR) as a metabolic marker(30-40 years of old)
- Circulating soluble intercellular adhesion molecule-1 (sICAM-1) as an inflammatory marker(30-40 years of old)
- Mid-arm circumference(30-40 years of old)
- Aortic compliance(30-40 years of old)
- Retinal venular structure(30-40 years of old)
- White matter hyperintensities volume(30-40 years of old)
- Circulating soluble fms-like tyrosine kinase-1 (sFlt-1) as an antiangiogenic marker(30-40 years of old)
- Circulating fasting insulin concentration as a metabolic marker(30-40 years of old)
- Circulating soluble vascular cell adhesion molecule-1 (sVCAM-1) as an inflammatory marker(30-40 years of old)
- Body weight(30-40 years of old)
- Waist-to-hip ratio(30-40 years of old)
- Diastolic blood pressure(30-40 years of old)
- Pulse pressure(30-40 years of old)
- Cardiac right ventricular stroke volume(30-40 years of old)
- Cardiac left ventricular stroke volume(30-40 years of old)
- Cardiac right ventricular systolic function(30-40 years of old)
- Cardiac right ventricular diastolic function(30-40 years of old)
- Morphology of the right ventricles(30-40 years of old)
- Total grey matter volume(30-40 years of old)
- Subcortical brain volume of thalamus(30-40 years of old)
- Cerebral vessel lumen diameter(30-40 years of old)
- Arterial cerebral blood volume fraction(30-40 years of old)
- Circulating total cholesterol as a metabolic marker(30-40 years of old)
- Circulating high-density lipoprotein as a metabolic marker(30-40 years of old)
- Circulating triglycerides as a metabolic marker(30-40 years of old)
- Circulating fasting glucose concentration as a metabolic marker(30-40 years of old)
- Circulating C-reactive protein (CRP) as an inflammatory marker(30-40 years of old)
- Body mass index(30-40 years of old)
- Systolic blood pressure(30-40 years of old)
- Heart rate(30-40 years of old)
- Morphology of the left ventricles(30-40 years of old)
- Intra-hepatic lipid content, steatohepatitis and hepatic fibrosis(30-40 years of old)
- Total white matter volume(30-40 years of old)
- Cerebral vessel tortuosity(30-40 years of old)
- Whole brain grey matter perfusion or cerebral blood flow (CBF)(30-40 years of old)
- Body height(30-40 years of old)
- Smoking status(30-40 years of old)
- Alcohol consumption(30-40 years of old)
- Cardiac left ventricular mass(30-40 years of old)
- Cardiac left ventricular end-diastolic volume(30-40 years of old)
- Cardiac left ventricular diastolic function(30-40 years of old)
- Oxygen uptake across sub-maximal and peak exercise(30-40 years of old)
- Retinal arteriolar structure(30-40 years of old)
- Retinal arteriolar-to-venular diameter ratio (AVR)(30-40 years of old)
- Ear microvascular structure(30-40 years of old)
- Lung function(30-40 years of old)
- Subcortical brain volume of hippocampus(30-40 years of old)
- White matter hyperintensities count(30-40 years of old)
- Cerebral vessel density(30-40 years of old)
- Circulating vascular endothelial growth factor A (VEGF-A) as an angiogenic marker(30-40 years of old)
- Circulating soluble endoglin (sENG) as an angiogenic marker(30-40 years of old)
- Circulating low-density lipoprotein as a metabolic marker(30-40 years of old)
- Mean arterial pressure(30-40 years of old)