An Observational Study of Predictors and Outcomes of Lung Cancer in Never-smokers in the UK
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 225
- 试验地点
- 1
- 主要终点
- Demographics, comorbidities and environmental exposures of participants
研究概览
简要总结
The goal of this observational study is to improve the early detection of lung cancer in adults who have smoked less than 100 tobacco cigarettes ("never-smokers") in the United Kingdom. The main questions it aims to answer are:
- To describe characteristics such as demographics, co-morbidities and environmental exposures
- To describe participant pathways including presentation mode and symptoms to understand if earlier diagnosis would be possible
- To describe participant outcomes such as cancer stage, treatment and mortality
- To quantitatively or qualitatively measure modifiable and non-modifiable factors that may be associated with LCINS including environmental measures, blood tests and genomic data.
Participants will currently have no change to their usual care.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All adult participants from age of 18 who are diagnosed or treated with primary lung cancer through radiology or histology at any participating study site
排除标准
- •Participants who have ever smoked cigarettes or tobacco will be excluded; this is defined as:
- •More than 100 cigarettes or 75g tobacco in their lifetime
- •Those who have received a prescription for nicotine replacement therapy
- •For prospective participants, those who cannot consent will be excluded
结局指标
主要结局
Demographics, comorbidities and environmental exposures of participants
时间窗: Comorbidities and environmental exposures at diagnosis (approximately up to 156 weeks prior to diagnosis)
From review of electronic health records
Participant pathways including presentation mode and symptoms
时间窗: Presentation mode and symptoms at time of diagnosis (approximately up to 52 weeks prior to diagnosis)
From review of electronic health records
次要结局
- Participant outcomes such as cancer stage, treatment, mortality(Cancer stage at time of diagnosis, treatment and mortality through study completion (likely 5 years))
- Measurement of modifiable and non-modifiable factors associated with LCINS(Through study completion (likely 5 years))
研究者
Neal Navani
Professor of Respiratory Medicine
University College, London