Anti-thymocyte Globulin-induced Immune Senescence
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 97
- 试验地点
- 1
- 主要终点
- Percentage of senescent lymphocytes
研究概览
简要总结
The aim of the study is to investigate the impact of Anti-Thymocyte Globulin (ATG) on immune senescence. Markers of immune senescence expression is assessed in a prospective cohort of renal transplant recipients the day of transplantation and one year after renal transplantation.
详细描述
The anti-thymocyte globulin (ATG) are used in the prevention and treatment of acute rejection in organ transplantation. They are at the origin of a brutal CD4 lymphocyte depletion followed by a gradual recovery of the lymphocyte pool. Nevertheless, CD4 lymphopenia can persist in some patients.
SIGAL study aims to characterize the immune responses of lymphopenic patients (after administration of ATG) in order to identify possible similarities with immunosenescence.The immunosenescence is a complex and profound remodeling of the immune system during life. It is mainly due to thymic involution and repeated antigenic stimulation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient able to understand the reason of the study
- •Signature of informed consent
- •Patient who are waiting renal transplant
排除标准
- •Inability to understand the reasons for the study; psychiatric disorders
- •Any history in the last 2 years of immunosuppressive therapy (except steroids)
- •History of cancer (except skin cancer) or treated hematological malignancy
结局指标
主要结局
Percentage of senescent lymphocytes
时间窗: One year after kidney transplantation
Flow cytometry analysis (7 colors) of lymphocytes
次要结局
未报告次要终点