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临床试验/NCT06478303
NCT06478303招募中不适用

LAnguage-Motor Imagery Circuits to Improve Motor Learning and Language Comprehension

University Hospital, Grenoble2 个研究点 分布在 1 个国家目标入组 105 人开始时间: 2024年7月27日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
105
试验地点
2
主要终点
Level of corticospinal excitability

研究概览

简要总结

Recent evidence suggests that cognitive systems do not operate in isolation but interact within broader networks, thus opening new avenues for fundamental and clinical research. An illustrative example is the interaction between language comprehension and motor representations. For instance, motor training (e.g., sports, origami training) can facilitate action verb recognition, whereas motor deficits (e.g., upper limb immobilization) can hinder the processing of action language. Similarly, action language has been shown to affect motor performance. These effects are attributed to an implicit form of motor imagery, an automatic simulation of motor experience (without actual movement) evoked by action words. Interestingly, literature supports the idea that the motor simulations used for imagining an action are also engaged during the reading of action language, leading to similar neurophysiological and behavioral changes in both processes. However, questions remain about the similarity of the simulations generated by motor imagery and action language. This project, encompassing three experimental sequences, aims to address these questions to achieve significant scientific advancements in both theoretical and applied domains.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
18 Years 至 40 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • persons who have given written consent,
  • healthy subjects
  • subjects reading and understanding French
  • right-handed,
  • affiliated with a social security system,
  • between 18 and 40 years old,
  • had completed the TMS inclusion questionnaire or had undergone a medical examination prior to participation in the MRI study.

排除标准

  • Existence of a severe general medical condition: cardiac, respiratory, hematological, renal, hepatic, cancerous,
  • Regular use of anxiolytics, sedatives, antidepressants, neuroleptics,
  • Characterized psychiatric pathology,
  • Ingestion of alcohol prior to the examination,
  • Persons covered by articles L1121-5 to L1121-8 of the CSP,
  • Presence of contraindications to MRI or TMS.

结局指标

主要结局

Level of corticospinal excitability

时间窗: 1 hour and 30 minutes

this is a physiological response obtained by transcranial magnetic pulses (TMS). This is an indicator of the excitability of the motor system, which can be used at rest or during various cognitive tasks (motor imagery or action reading).

Cortical activation (BOLD signal)

时间窗: 1 hour

this is a cortical response obtained via a fMRI. This is an indicator of the brain activity, which can be used at rest or during motor and cognitive tasks (motor imagery or action reading).

次要结局

未报告次要终点

研究者

发起方
University Hospital, Grenoble
申办方类型
Other
责任方
Sponsor

研究点 (2)

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