Brain imaging responses to food in insulin resistance: a single centre non-randomised interventional screening trial

Kings College London (KCL)0 个研究点目标入组 100 人开始时间: 2010年12月14日最近更新: 2018年4月30日

适应症

试验速览

暂无简介。

•All subjects (insulin sensitive and insulin resistant):
•2. Age 18 - 65 years (inclusive at time of recruitment)
•3. Right-handed
•4. English speaking
•5. No active medical illness including diabetes mellitus
•6. Body mass index (BMI) less than or equal to 30 kg/m2
•Insulin sensitive subjects:
•7. No family history of diabetes mellitus
•8. Insulin sensitive (determined by homeostatic model assessment - insulin resistance [HOMA2-IR] during screening process)
•Insulin resistant subjects:
•9. First degree relatives of patients with type 2 diabetes mellitus
•10. Insulin resistance (determined by HOMA2-IR during screening process)

•2. Left-handedness
•3. Current of past history of significant substance abuse or eating disorder
•4. Neurological or psychiatric disorders
•5. Use of medication that may affect brain activity (e.g. antidepressants, anticonvulsants, antipsychotic drugs), drugs for obesity (orlistat or sibutramine) or drugs that lower glucose (e.g. metformin, sulphonylureas, thiazolidinediones, incretins or insulin)
•6. Inability to understand spoken and/or written English
•7. Claustrophobia (because of the small bore of the MR scanner)
•8. BMI greater than 30 kg/m2
•9. Contraindication to MRI (pacemaker in situ, extensive dental work, history of penetrating eye trauma, presence of metal surgical clips etc.)
•10. Presence of diabetes

发起方

Kings College London (KCL)