ISRCTN51099878已完成未知
Brain imaging responses to food images and food in insulin resistance: a single centre randomised observational treatment based case-control study
Kings College London (KCL)0 个研究点目标入组 48 人开始时间: 2010年12月14日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 48
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- Male
入选标准
- •All subjects (insulin sensitive and insulin resistant):
- •2. Age 18 - 65 years (inclusive at time of recruitment)
- •3. Right-handed
- •4. English speaking
- •5. No active medical illness including diabetes mellitus
- •6. Body mass index (BMI) less than or equal to 30 kg/m2
- •Insulin sensitive subjects:
- •7. No family history of diabetes mellitus
- •8. Insulin sensitive (determined by homeostatic model assessment - insulin resistance [HOMA2-IR] less than 1.47)
- •Insulin resistant subjects:
- •9. First degree relatives of patients with type 2 diabetes mellitus
- •10. Insulin resistance (determined by HOMA2-IR) greater than or equal to 1.47
排除标准
- •2. Left handedness
- •3. Current or past history of significant substance abuse or eating disorders
- •4. Use of medication that may affect brain activity (e.g. antidepressants, anticonvulsants, antipsychotic drugs), drugs for obesity (orlistat or sibutramine) or drugs that lower glucose (e.g. metformin, sulphonylureas, thiazolidinediones, incretins or insulin)
- •5. Inability to understand spoken and/or written English
- •6. Claustrophobia (because of the small bore of the MR scanner)
- •7. BMI greater than 30 kg/m2
- •8. Cortraindication to MRI (pacemaker in situ, extensive dental work, history of penetrating eye trauma, precense of surgical metal clips etc.)
- •9. Presence of diabetes
研究者
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