ISRCTN51099878
Completed
未知
Brain imaging responses to food images and food in insulin resistance: a single centre randomised observational treatment based case-control study
Kings College London (KCL)0 sites48 target enrollmentDecember 14, 2010
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Kings College London (KCL)
- Enrollment
- 48
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •All subjects (insulin sensitive and insulin resistant):
- •2\. Age 18 \- 65 years (inclusive at time of recruitment)
- •3\. Right\-handed
- •4\. English speaking
- •5\. No active medical illness including diabetes mellitus
- •6\. Body mass index (BMI) less than or equal to 30 kg/m2
- •Insulin sensitive subjects:
- •7\. No family history of diabetes mellitus
- •8\. Insulin sensitive (determined by homeostatic model assessment \- insulin resistance \[HOMA2\-IR] less than 1\.47\)
- •Insulin resistant subjects:
Exclusion Criteria
- •2\. Left handedness
- •3\. Current or past history of significant substance abuse or eating disorders
- •4\. Use of medication that may affect brain activity (e.g. antidepressants, anticonvulsants, antipsychotic drugs), drugs for obesity (orlistat or sibutramine) or drugs that lower glucose (e.g. metformin, sulphonylureas, thiazolidinediones, incretins or insulin)
- •5\. Inability to understand spoken and/or written English
- •6\. Claustrophobia (because of the small bore of the MR scanner)
- •7\. BMI greater than 30 kg/m2
- •8\. Cortraindication to MRI (pacemaker in situ, extensive dental work, history of penetrating eye trauma, precense of surgical metal clips etc.)
- •9\. Presence of diabetes
Outcomes
Primary Outcomes
Not specified
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