Brain imaging responses to food images and food in insulin resistance - interventio

Not Applicable

Completed

• Conditions: Topic: Diabetes Research Network; Disease: Obesity; Nutritional, Metabolic, Endocrine; Obesity; Subtopic: Type 2

• Registration Number: ISRCTN51099878
• Lead Sponsor: Kings College London (KCL)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-12-14
• Study Completion: 2013-11-01
• Last Update Posted: 30 April 2018

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 48

Inclusion Criteria

All subjects (insulin sensitive and insulin resistant):
1. Men
2. Age 18 - 65 years (inclusive at time of recruitment)
3. Right-handed
4. English speaking
5. No active medical illness including diabetes mellitus
6. Body mass index (BMI) less than or equal to 30 kg/m2

Insulin sensitive subjects:
7. No family history of diabetes mellitus
8. Insulin sensitive (determined by homeostatic model assessment - insulin resistance [HOMA2-IR] less than 1.47)

Insulin resistant subjects:
9. First degree relatives of patients with type 2 diabetes mellitus
10. Insulin resistance (determined by HOMA2-IR) greater than or equal to 1.47

Exclusion Criteria

1. Women
2. Left handedness
3. Current or past history of significant substance abuse or eating disorders
4. Use of medication that may affect brain activity (e.g. antidepressants, anticonvulsants, antipsychotic drugs), drugs for obesity (orlistat or sibutramine) or drugs that lower glucose (e.g. metformin, sulphonylureas, thiazolidinediones, incretins or insulin)
5. Inability to understand spoken and/or written English
6. Claustrophobia (because of the small bore of the MR scanner)
7. BMI greater than 30 kg/m2
8. Cortraindication to MRI (pacemaker in situ, extensive dental work, history of penetrating eye trauma, precense of surgical metal clips etc.)
9. Presence of diabetes

Study & Design

• Study Type: Interventional
• Study Design: Not specified