Functional MRI during cognitive processing of food stimuli in chronically ill and recovered women with anorexia nervosa

Completed

• Conditions: Anorexia Nervosa; Anorexia.; 10003018

• Registration Number: NL-OMON33446
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 12 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 45

Inclusion Criteria

- Right-handed
- Chronically ill AN patients should have suffered from the illness for at least two years (as defined by the DSM IV criteria) and have a BMI below 17.5 kg/m2.
- The women recovered from AN should be weight-recovered for at least 1 year (BMI > 17.5 kg/m2) and have a regular menstrual cycle
- Healthy control women should have a normal BMI, i.e. between 18.5 and 25 kg/m2 and a regular menstrual cycle.

Exclusion Criteria

- Contra-indications to MRI scanning on the basis of the MRI screening form, including: Claustrophobia, pregnancy, metal objects in the body incompatible with MRI scanning.
- Having a history of or current excessive alcohol consumption (> 28 units per week)
- Having a drug dependency
- Smoking daily
- Having a history of medical or surgical events that may significantly affect the study outcome.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1) The brain activation associated with viewing food stimuli. 2) Serum<br /><br>concentrations of leptin, ghrelin and PYY. 3) Measures of cognitive<br /><br>functioning, in particular the Wisconsin Card Sorting Test (set shifting<br /><br>ability), and the Iowa Gambling Task (decision making performance). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1) Subjective ratings of the desire to eat, 2) Subjective ratings of anxiety,<br /><br>3) Energy intake (kJ) from the test meal.</p><br>