NCT00617721终止不适用
Defect in Cell Stimulation and Unexplained hemorrhagesMarkers Related to Membrane Remodelling in the Prognosis Scott-like Syndormes
University Hospital, Strasbourg, France5 个研究点 分布在 2 个国家目标入组 29 人开始时间: 2008年6月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 29
- 试验地点
- 5
研究概览
简要总结
Purpose: Identification of the gene(s) involved in plasma membrane remodelling. Identification of the circulating markers affected by the defective membrane remodelling in a collection of families with unexplained provoked hemorrhages and evaluation of their prognosis value in the assessment of the hemostatic cellular response.Hypothesis: Scott syndrome is rare a familial disorder characterized by provoked haemorrages in homozygous-type patients due to isolated membrane remodelling deficiency. Membrane remodelling is necessary for cellular hemostatic responses.
研究设计
- 研究类型
- Observational
- 观察模型
- Family Based
- 时间视角
- Prospective
入排标准
- 年龄范围
- 2 Years 至 80 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with unexplained provoked hemorrhages (surgery, tooth extraction, birth ...), and associated with reduced prothrombin consomption (residual prothrombine in serum > à 5%).
- •Family members of the patients defined above, with or without unexplained hemorrhages (symptomatic or not).
- •Patient's approval based on detailed information given by the pratician
排除标准
- •Patients with primary hemostasis defect or defective blood coagulation factor(s) possibly explaining the bleeding disorder.
- •patients known to be affected by Factor V New York .
- •Patients enrolled in a previous clinical study, the exclusion period of which is not yet completed. - Collaboration to the study rejected by the patient
- •Patients that are not registered for medical care social insurance.
研究者
研究点 (5)
Loading locations...
相似试验
招募中
不适用
Cellular Mechanisms Involved in Muscle PathologyMuscle Strain, Lower LegMuscle Strained ThighFatty DegenerationAchilles Tendon LacerationNCT05798962Bispebjerg Hospital30
Unknown
不适用
Sterile Inflammation and Molecular Aberrations in MDSMyelodysplastic SyndromesNCT04313231Medical University Innsbruck130
招募中
不适用
Molecular Studies on Hereditary Haemorrhagic Telangiectasia FamiliesTelangiectasia, Hereditary HemorrhagicNCT00230620Imperial College London1,000
Unknown
不适用
Genomic/Epigenomic Biomarkers of Deregulation of Immune System in Inflammatory Bowel DiseasesCrohn DiseaseNCT02878395Central Hospital, Nancy, France30
招募中
不适用
Complex Molecular Etiology and Cellular Landscape of Hip OsteoarthritisOsteoarthritis, HipRheumatoid ArthritisNCT05278520University of Turku110