Investigating Significant Health Trends in IPF (INSIGHTS-IPF). Nationwide Prospective Registry.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,232
- 试验地点
- 5
- 主要终点
- Clinical course of IPF (in terms of symptoms, lung function, survival)
研究概览
简要总结
Idiopathic pulmonary fibrosis (IPF), a manifestation of chronic progressive fibrosing interstitial pneumonia,ia a rare disease. Current treatment options are limited, and the mean survival time of the newly diagnosed (mostly elderly) patients is only about 2-3 years. As in Europe data are limited on the characteristics and management of such patients, INSIGHTS-IPF was initiated as a new registry that documents newly diagnosed (incident) and prevalent patients with confirmed IPF diagnosis prospectively.The registry will contribute to the optimization of the management of IPF patients in the long term.
详细描述
INSIGHTS-IPF will report current and comprehensive data on Idiopathic Pulmonary Fibrosis (IPF) in the long-term.
Baseline (cross-sectional part): Description of characteristics of IPF patients in terms of
- key (socio-) demographic data
- IPF risk factors, comorbidities
- methods used for IPF diagnosis
- IPF disease severity and manifestation (including lung function, cardiopulmonary exercise testing and/or exercise capacity if available, laboratory values, biomarkers)
- IPF treatment (detailed information on prescribed drugs and doses; non-pharmacological treatment; listing and score for lung transplantation)
- assessment of patient-related outcomes (PRO) such as quality of life
Follow-up (prospectively up to at least 2 years after inclusion):
- Clinical course of IPF (e.g. in terms of symptoms, lung function, exercise capacity if available)
- Documentation of treatment pathways (switch/add-on/discontinuation of medication), and of non-pharmacological treatment (e.g. start of long term oxygen therapy; new listing for lung transplantation)Outcomes/events (such as acute respiratory worsening, exacerbations, hospitalisation due to any cause and due to IPF, other complications, survival)
- Patient-related outcomes such as quality of life, assessed once a year(for comparison with baseline)
- Resource use for pharmacoeconomic analyses.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •At least 18 years of age
- •Written informed consent for participation in the registry
- •Newly diagnosed (incident) or known (prevalent) IPF (based on diagnosis of treating physician)
排除标准
- 未提供
结局指标
主要结局
Clinical course of IPF (in terms of symptoms, lung function, survival)
时间窗: up to 5 years after inclusion
次要结局
- Treatment pathways(up to 5 years after inclusion)
- Characteristics of patients with IPF(up to 5 years after inclusion)
- Functionality and quality of life(up to 5 years after inclusion)