The Effect of Dexmedetomidine on Blood Coagulation: In Vitro, Volunteer Study Using Rotational Thromboelastometry
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11
- 试验地点
- 1
- 主要终点
- FIBTEM
研究概览
简要总结
Dexmedetomidine may alter whole blood coagulation. However, little is known about the dose-response relationships according to the blood concentration of dexmedetomidine. The investigators have therefore performed the present study to measure the effect of dexmedetomidine on the coagulation pathway according to the drug concentration level using a rotational thromboelastometry test.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers
- •Age: 20 to 65 years
- •Body weight > 50 kg
- •Volunteers who provided informed consent
排除标准
- •Hematologic disease
- •Anticoagulant medication
研究组 & 干预措施
0 ng/ml
Blood specimen which was added 0 ul of dexmedetomidine
干预措施: 0 ul of dexmedetomidine (Drug)
0.5 ng/ml
Blood specimen which was added 0.25 ul of dexmedetomidine
干预措施: 0.25 ul of dexmedetomidine (Drug)
1.0 ng/ml
Blood specimen which was added 0.5 ul of dexmedetomidine
干预措施: 0.5 ul of dexmedetomidine (Drug)
1.5 ng/ml
Blood specimen which was added 0.75 ul of dexmedetomidine
干预措施: 0.75 ul of dexmedetomidine (Drug)
结局指标
主要结局
FIBTEM
时间窗: During the rotational thromboelastometry analysis/ an average of 1 hour
Fibrinolytic pathway values of rotational thromboelastometry analysis/ FIBTEM is not an acronym.
次要结局
- EXTEM(During the rotational thromboelastometry analysis/ an average of 1 hour)
- INTEM(During the rotational thromboelastometry analysis/ an average of 1 hour)
研究者
Hyo-Seok Na
Associate Professor
Seoul National University Bundang Hospital