Influence of dexmedetomidine on hemodynamic parameters in critical ill patients

Not Applicable

Completed

• Conditions: Critically ill patients with occurring delirium after admission to ICU; Mental and Behavioural Disorders; Delirium, unspecified

• Registration Number: ISRCTN13101129
• Lead Sponsor: Klinikum rechts der Isar der TU München

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-08-22
• Last Update Posted: 11 September 2017

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

Critically ill patients (18 years and older) with occurring delirium after admission to ICU. For delirium screening the Confusion Assessment Method (CAM-ICU) and Richmond Agitation-Sedation-Scale (RASS) were used.

Exclusion Criteria

1. Younger than 18 years
2. Pregnancy
3. Known drug intolerance or allergy against dexmedetomidine
4. Increased intracranial pressure
5. Patients with cerebrale pathology, which changes the controllability of sedation or die consciousness
6. Myasthenia Gravis
7. Cerebellar or spinal Ataxia
8. Enzyme related disorders that are associated with a severe decreased activity of UDP-glucoronyltransferase (e.g. M. Crigler- Najjar)
9. Chronic liver insufficiency CHILD A, B or C

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cardiac power index is measured using the transpulmonary thermodilution technique (PiCCO) at the individual maximum dosage of dexmedetomidine (0.3µg/kg/h or 0.7µg/kg/h) and compared to baseline values (dexmedetomidine, 0 µg/kg/h)