NCT02634021撤回4 期
Hemodynamic Change Between Loading of Dexmedetomidine or Midazolam as a Sedative Agents During Knee Arthroscopy
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- change of heart rate
研究概览
简要总结
Loading dose of dexmedetomidine is related hemodynamic instability such as bradycardia and hypertension.
详细描述
The investigators hypothesized substitution of loading of dexmedetomidine for midazolam could reduce hemodynamic instability during spinal anesthesia for knee arthroscopy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients who were planned to undergo knee arthroscopy under spinal anesthesia
排除标准
- •age < 20 years
- •underlying heart, liver or kidney disease
- •hypersensitivity to midazolam or dexmedetomidine
研究组 & 干预措施
dexmedetomidine group
Active Comparator
dexmedetomidine 1 mcg/kg intravenous loading followed by dexmedetomidine continuous infusion at the rate of 0.5 mcg/kg/hr
干预措施: dexmedetomidine group (Drug)
midazolam group
Experimental
midazolam 0.1 mg/kg intravenous loading followed by dexmedetomidine continuous infusion at the rate of 0.5 mcg/kg/hr
干预措施: midazolam group (Drug)
结局指标
主要结局
change of heart rate
时间窗: from 1 minute before anesthesia to 1 hr after anesthesia
次要结局
- change of bispectral index(from 1 minute before anesthesia to 1 hr after anesthesia)
研究者
Seong-Hyop Kim
Professor
Konkuk University Medical Center
研究点 (1)
Loading locations...
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