跳至主要内容
临床试验/NCT07056270
NCT07056270尚未招募不适用

Development of a Set of Auxiliary Decision-making System for the Perioperative Period of Hepatectomy Based on Static CT and Artificial Intelligence.

Tongji Hospital0 个研究点目标入组 500 人开始时间: 2025年8月1日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
500
主要终点
microvascular invasion

研究概览

简要总结

The study will prospectively recruit patients with chronic liver disease and liver cancer for static CT scans to establish a high-definition CT database. Combining clinical data and pathological information, artificial intelligence technology will be utilized to construct models for assessing liver function and liver cirrhosis, as well as predicting microvascular invasion (MVI).

详细描述

Liver cancer is a common disease that seriously endangers public health in China, and CT technology is particularly critical in the diagnosis and treatment of liver cancer. Most patients with liver cancer in China are complicated with liver cirrhosis, and the treatment principle is a comprehensive model based on surgical resection. The main problem in the perioperative period of hepatectomy is to accurately evaluate the grade of cirrhosis, liver reserve function and predict microvascular invasion (MVI) before operation. In view of these problems, this project plans to develop a set of auxiliary decision-making system for the perioperative period of hepatectomy of liver cancer based on static CT and artificial intelligence technology and combined with expert consensus. The system will first establish a set of high-quality liver health/disease image database based on static CT (slice thickness 0.165mm, 2048×2048 scanning/reconstruction matrix, multi-energy spectrum), providing high-quality data source for clinical application development; Then, use artificial intelligence technology to optimize the output high-quality data, data mining and learning, and carry out targeted analysis from the aspects of liver cirrhosis grading, liver reserve function and MVI evaluation; Finally, on the basis of evidence-based medicine and expert consensus, intelligently fuse the multimodal biomedical information to form a set of auxiliary decision-making system for the perioperative period of hepatectomy for liver cancer, which provides a new method for further standardizing the diagnosis and treatment behavior of liver cancer and improving the surgical treatment effect of liver cancer.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 75 Years(Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •Patients who are clinically diagnosed with primary liver cancer and other space-occupying liver lesions preoperatively and are planned for surgical resection, or those with underlying liver diseases and cirrhosis;
  • •Aged 18-75 years;
  • •Willing to participate in this study and have signed the informed consent.

排除标准

  • •Planned or unplanned pregnancy and pregnant women;
  • •Glomerular filtration rate (GFR) ≤60 ml/min;
  • •History of contrast media allergy.

结局指标

主要结局

microvascular invasion

时间窗: 7 days after surgery

microvascular invasion based on pathology

liver cirhosis

时间窗: 7 days after surgery

liver cirhosis according to laennec grading system

liver function

时间窗: 1 day before static CT scanning

liver funcion based Child-Pugh grading system

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Chen Xiaoping

Chairman of the Department of Surgery

Tongji Hospital

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