Comparison of MR Elastography Methods Without and With Compressed Sensing
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Standard Magnetic Resonance Elastography versus Elastography with Compressed Sensing (x1.5)
研究概览
简要总结
In this research study, the investigators will compare the liver stiffness results obtained from the current Magnetic Resonance Imaging (MRI) method to liver stiffness results obtained from a method that uses faster imaging techniques.
详细描述
MR elastography is increasingly used to assess liver stiffness in pediatric and adult patients with chronic liver diseases. While numerous tissue abnormalities can affect liver stiffness, liver stiffness measured by MR elastography is most often used to predict and quantify liver fibrosis. Conventional MR elastography techniques require multiple breath-holds that are 12-20 seconds in length. In the pediatric population, reliable breath-holding >10 seconds can be challenging. Recently, compressed sensing has become available as a method for accelerating image data acquisition, and thus shortening breath-holds.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult volunteers ≥18 years of age
- •Ability to tolerate 30 minutes in an MRI scanner.
- •Nothing to eat or drink for 4 hours prior to the MRI scan
排除标准
- •No contraindication to MR imaging (e.g., implanted non-MRI compatible device)
- •Known or suspected pregnancy. Female subjects of child bearing potential will undergo a urine pregnancy test prior to imaging.
结局指标
主要结局
Standard Magnetic Resonance Elastography versus Elastography with Compressed Sensing (x1.5)
时间窗: 30 minutes
Four MR elastography images through the mid liver will be obtained using standard MR elastography and MR elastography with 1.5 times the amount of standard Sensing applied. Correlation Coefficient will be determined for resulting elastography data.
Standard Magnetic Resonance Elastography versus Elastography with Compressed Sensing (x2)
时间窗: 30 minutes
Four MR elastography images through the mid liver will be obtained using standard MR elastography and MR elastography with 2 times the amount of standard sensing applied. correlation coefficient will be determined for resulting elastography data.
Standard Magnetic Resonance Elastography versus Elastography with Compressed Sensing (x3)
时间窗: 30 minutes
Four MR elastography images through the mid liver will be obtained using standard MR elastography and MR elastography with 3 times the amount of standard Sensing applied. Correlation coefficient will be determined for resulting elastography data.
次要结局
- Standard Magnetic Resonance Elastography versus navigated triggered Magnetic Resonance Elastography.(30 minutes)
- Standard Magnetic Resonance Elastography versus respiratory triggered Magnetic Resonance Elastography.(30 minutes)