MIDNOR-TIA - a Prospective Cohort Study of 600 TIA Patients in Central Norway
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 584
- 试验地点
- 8
- 主要终点
- Number of patients presenting with stroke within 1 week after transient ischemic attack
研究概览
简要总结
Patients with a transient ischemic attack (TIA) are at high risk of stroke. Rapid assessment and treatment can reduce the risk. Several international guidelines recommend a test, the ABCD2 score, to identify TIA patients with low and high risk for stroke. The main purpose of this study is to investigate stroke risk after TIA in both short (1 week) and long term (3 months/1 year), and to assess whether the ABCD2 score ('Age, blood pressure, clinical features, duration of TIA, diabetes score) is an adequate tool for predicting stroke risk. Secondary aims are to explore whether adopting imaging modalities (ultrasound, MRI) and biological markers of blood into a risk score could improve the predictive value of the ABCD2 score and still be feasible in a daily clinical practice. Further on overall risk factors in TIA patients, and the incidence of other vascular events will be studied. A substudy designed as a randomised controlled trial evaluates pharmaceutical counseling in a subset of participants. Cost-benefit analysis, and a long-term follow-up (5 years) is planned.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Probable or possible transient ischemic attack
- •Residing in Central Norway
- •Examined within 2 weeks after the onset of symptoms
- •Modified Rankin Scale 3 or less and living at home
- •Informed consent
排除标准
- 未提供
结局指标
主要结局
Number of patients presenting with stroke within 1 week after transient ischemic attack
时间窗: 1 week
Measured by using data from the Norwegian Stroke Registry
次要结局
- Incidence of other vascular events within 3 months after transient ischemic attack(3 months)
- Incidence of other vascular events within 1 year after transient ischemic attack(1 year)
- Number of patients presenting with stroke within 3 months after transient ischemic attack(3 months)
- Correlation between the ABCD2 score and the incidence of stroke within 3 months after transient ischemic attack(3 months)
- Incidence of other vascular events within 1 week after transient ischemic attack(1 week)
- Number of patients presenting with stroke within 1 year after transient ischemic attack(1 year)
- Cost-benefit analysis(1 year)
- Correlation between the ABCD2 score and the incidence of stroke within 1 week after transient ischemic attack(1 week)
- Correlation between the ABCD2 score and the incidence of stroke within 1 year after transient ischemic attack(1 year)