May Covid-19 Impair Executive Functions? A Crossectional Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 128
- 试验地点
- 1
- 主要终点
- Neuropsychological test scores
研究概览
简要总结
As it is evident that Covid-19 may have some impacts on cognition, the primary aim of this study is to investigate -if any- deficits of attention, working memory and executive functions after Covid-19.
详细描述
Since Covid-19 (Coronavirus Disease-2019) was declared as a pandemic by the World Health Organization (WHO) on December 31, 2019, it is still widespread and deadly. As an ongoing pandemic, it has led to a panic and then a controlled fear in societies. In many studies, neuropsychological deficits were observed in Covid-19 patients both during the illness and after recovery. A recent study found that impairment in cognitive functions continued after recovery of Covid-19, and it was associated with peripherical inflammatory markers, such as C-Reactive Protein (CRP). CRP, as a peripherical inflammatory marker, has been proven to be inversely related to serum levels of the brain-derived neurotrophic factor (BDNF), an important neurotrophin in the growth and differentiation of neurons. In this study, attention, working memory and executive functions of Covid-19 patients at post-covid period and its relation with the severity of the disease will be investigated.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Covid-19 patients:
- •Diagnosed as Covid-19 by RT-PCR at least 60 days but not more than 90 days ago
- •Asymptomatic at the moment
- •Not having any other general medical, neurological or psychiatric conditions except Covid-19 at the time of acute infection
- •Healthy subjects:
- •Not having any of Covid-19 symptoms at the testing time point
- •Not having any general medical, neurological or psychiatric condition
排除标准
- •Covid-19 patients:
- •Diagnosed as Covid-19 by RT-PCR less than 60 days or more than 90 days ago
- •Having any symptom of acute phase of Covid-19
- •Having any other general medical, neurlogical or psychiatric contidions
- •Healthy subjects:
- •Having any of Covid-19 symptoms at the testing time point
- •Having any general medical, neurological or psychiatric condition
结局指标
主要结局
Neuropsychological test scores
时间窗: Up to 90 days
Neuropsychological test scores of Covid-19 patients in comparison with healthy control subjects
次要结局
- Severity of the disease(Up to 90 days)
研究者
Mehmet Diyaddin Güleken
Medical Doctor
Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital