Attenuation of hemodynamic response to laryngoscope & endotracheal intubation with preinduction dexmeditomedine nebulization versus sublingual nitroglycerin spray in patients undergoing elective surgeries - a prospective randomised comparative study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Attenuation of intubation response with dexmeditomedine nebulization versus sublingual nitroglycerin spray
研究概览
简要总结
This study is a prospective randomised comparative study for attenuation of hemodynamic response to laryngoscopy and endotracheal intubation with preinduction dexmeditomedine nebulization versus sublingual nitroglycerin spray in patients undergoing elective surgeries
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Open Label
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Age group
- •60 years Both genders ASA grade I and II.
排除标准
- •Patient refusal Pregnancy Emergency surgery Patient with anticipated difficult airway Modified mallampatti III and IV Laryngoscope and intubation time >20s Obese patients with BMI >30kg/m2 H/o chronic hepatic renal or cardiac disease H/o drug allergy.
结局指标
主要结局
Attenuation of intubation response with dexmeditomedine nebulization versus sublingual nitroglycerin spray
时间窗: Baseline | At induction | 1 min after induction | 2 min after induction | 3 min after induction | At intubation | 1 min after intubation | 2 min after intubation | 3 min after intubation | 5 min after intubation | 10 min after intubation | 15 min after intubation | 30 min after intubation | At extubation | 5 min after extubation | 10 min after extubation | 15 min after extubation | 20 min after extubation | 25 min after extubation | 30 min after extubation
次要结局
- Adverse effects of dexmeditomedine and nitroglycerin(24 hours)