Renal Arterial Resistive Index as a Noninvasive Biomarker of Disease Activity in Lupus Nephritis Patients
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 55
- 试验地点
- 1
- 主要终点
- doppler for renal artery
研究概览
简要总结
Systemic Lupus Erthymatosous (SLE) is achronic inflammatory multi system auto immue disease characterized by pathogenic auto anti bodies production against nuclear structures (Bolouri et al.,2022), SLE affecting mainly woemn of childbearing age and is chracterized by unpredictable flares and remissions , disease variety varied from mild episode disorder to arpidly progressive life -threatening illness..
LN is diagnosed by either the presence of proteinuria >0.5g/day. active urinary sediment , or an unexplained rise in serum creatinine there fore , identifying new invasive biomarkers of LN severity and outcome is mandatory, Renal Arterial resistive index ( RRI) is anon invasive biomarker that has been studied as apotential indicator of disease activity in LN patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged ≥18 years.
- •SLE patients fulfilling the SLE International Collaborating Clinics (SLICC) classification criteria and matched controls.
- •Patients cooperative and can answer questions.
- •Patients who are able and willing to give written informed consent.
排除标准
- •• Individuals with other autoimmune diseases.
- •Diabetes.
- •Hypertension.
- •Heart failure.
- •Hepatic diseases.
- •Chronic renal failure.
- •Renal artery stenosis.
- •Renal vein thrombosis.
- •Intrarenal arteriovenous fistula.
- •Obstructive nephropathy.
- •Urinary tract obstruction that could affect RI of intra renal arteries.
- •Un cooperative patients.
- •Patients not able and willing to give written informed consent.
结局指标
主要结局
doppler for renal artery
时间窗: 1 year
resistive index of renal artery
次要结局
未报告次要终点
研究者
Doaa Rabea Abdelkarim
resident at rheumatology and rehabilitation department
Sohag University