NL-OMON30824已完成不适用
Apathy in patients with Parkinson*s disease and major depressive disorder, a structural brain imaging study using Voxel Based Morphometry - Imaging and Apathy in patients with Parkinson*s disease
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Idiopathic Parkinson*s disease as defined by the criteria of the United Kingdom Parkinson*s Disease Brain Bank, regarding the inclusion of Parkinson*s disease patients (Hughes, Daniel et al. 1992).
- •- Apathy as defined by a score equal or higher than four on the apathy subscale of the Neuro Psychiatric Inventory (NPI), regarding the apathy groups (Cummings, Mega et al. 1994; Cummings 1997).
- •- Depression as defined by the criteria stated in the DSM-IV, regarding the depressed patients (DSM-IV 1994).
- •- Informed consent.
排除标准
- •- Other concurrent neurological diseases than PD.
- •- Concurrent psychiatric diseases (e.g. dementia).
- •- Use of psychopharmacological medication.
- •- Abuse of alcohol and/or drugs.
- •- Cognitive deterioration as operationalised by a score of <23 on the Mini Mental Status Examination (MMSE) (Folstein, Folstein et al. 1975).
- •Voxel Based Morphometry exclusion criteria:
- •- Pacemaker.
- •- Hart valve prosthesis.
- •- Metal fragments in brain or surrounding tissue.
- •- Ear implants.
- •- Claustrophobia.
- •- Infusion pumps.
- •- Pregnancy.
研究者
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