Resistance Training and Muscle - Brain Crosstalk
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Change in cognitive function on the Switching task (executive function)
研究概览
简要总结
BRAIN-M is a randomized controlled trial designed to examine the effects of a single bout or 12 weeks of blood-flow restriction training or high-intensity resistance training on cognitive function, brain health, muscular properties and physical performance in healthy older men 60-75 years old.
详细描述
The BRAIN-M project is driven by the idea that understanding the mechanisms through which muscle and brain interact could offer new approaches to magnifying the beneficial and detrimental effects of exercise training on health at older age. Specifically, the investigators aim at identifying brain, blood, and muscle biomarkers that could serve as predictors of response to exercise training at either cognitive, brain, muscle or physical performance levels and study the associations between biomarkers in order to suggest a physiological model of brain-muscle and muscle-brain crosstalk in ageing. 60 male older adults (60-75y old) will be included in either 12 weeks of high-intense blood-flow restriction training (n = 20), muscle damaging resistance training (n = 20) or no exercise (n = 20). The control group will be asked to maintain their usual lifestyle.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 75 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy male older adults
- •able to speak and read fluent Lithuanian
- •living in community during the study
排除标准
- •cognitive and neurological disorders (e.g. dementia, stroke, Parkinson, multiple sclerosis)
- •previous lower extremity injury
- •diabetes mellitus type I or II
- •no oncologic disease
- •no bone fractures in the previous year
- •deep vein thrombosis
- •cardiovascular disorders (e.g. congestive heart failure, angina pectoris, uncontrolled arrhythmia, history of myocardial infarction or coronary bypass grafting in the past year)
- •obesity (BMI >30kg/m²)
- •chronic fatigue, chronic headache, or chronic dizziness
- •ineligibility to MRI scanning (e.g. due to claustrofobia or metal implants)
- •The participants should not be engaged in any regular exercise programme during the previous 6 months (according to IPAQ), but able to perform 10 sit-ups
- •Any other consideration that interferes with the study aims and/or risk to the participant, at the discretion of the researcher
结局指标
主要结局
Change in cognitive function on the Switching task (executive function)
时间窗: Before first exercise bout, immediately after first exercise bout, 1 hour after the first exercise bout and after the 12 week intervention period
The switching task is a complex task where subjects need to switch (executive function) between a manikin task (visuospatial skill, attention and problem solving) and a mathematical computation task (mathematical computation skill, concentration and working memory).
次要结局
- Changes in handgrip strength(Before and after the 12 week intervention period)
- Changes in patellar tendon crossectional area(Before and after the 12 week intervention period)
- Change in cognitive function on the 2-Choice Reaction time (processing speed), Go/No-Go (inhibition) or 6 letter Memory Search (memory) test(Before first exercise bout, immediately after first exercise bout, 1 hour after the first exercise bout and after the 12 week intervention period)
- Changes in blood serum levels of TNFalpha and syndecan(Before first exercise bout, immediately after first exercise bout, 1 hour after the first exercise bout)
- Changes in blood serum levels of IGF-1, IL-6 and kynurenine(Before and after the 12 week intervention period)
- Changes in muscle contractile characteristics (with tensiomyography (TMG))(Before and after the 12 week intervention period)
- Changes in quadriceps muscle thickness(Before and after the 12 week intervention period)
- Changes in quadriceps muscle fiber type(Before and after the 12 week intervention period)
- Changes in BMI(Before and after the 12 week intervention period)
- Changes in SMI(Before and after the 12 week intervention period)
- Changes in quadriceps muscle fascicle angle(Before and after the 12 week intervention period)
- Changes in maximal isometric strength (with Biodex)(Before and after the 12 week intervention period)
- Changes in lactate levels(Before first exercise bout, immediately after first exercise bout, 1 hour after the first exercise bout)
- Changes in blood plasma levels of BDNF(Before first exercise bout, immediately after first exercise bout, 1 hour after the first exercise bout and after the 12 week intervention period)
- Changes in fat free mass(Before and after the 12 week intervention period)
- Changes in patellar tendon stiffness(Before and after the 12 week intervention period)
- Changes in quadriceps muscle fascicle length(Before and after the 12 week intervention period)
- Changes in quadriceps muscle intramuscular fat(Before and after the 12 week intervention period)
- Changes in brain white matter volume (with magnetic resonance imaging)(Before and after the 12 week intervention period)
- Changes in isokinetic peak torque (with Biodex)(Before and after the 12 week intervention period)
- Changes in subjective sleep quality (patient reported outcome questionnaires)(Before and after the 12 week intervention period)
- Changes in blood CK levels(Before first exercise bout and every 3 weeks for a total of 7 times 48 hours after the eccentric-only training session in the MDRT group.)
- Changes in body fat %(Before and after the 12 week intervention period)
- Changes in quadriceps muscle cross-sectional area(Before and after the 12 week intervention period)
- Changes in brain neural integrity (with proton magnetic resonance spectroscopy)(Before and after the 12 week intervention period)
- Changes in brain neuroinflammation (with proton magnetic resonance spectroscopy)(Before and after the 12 week intervention period)
- Changes in reported physical activity levels (patient reported outcome questionnaires)(Before and after the 12 week intervention period)
- Changes in brain gray matter volume (with magnetic resonance imaging)(Before and after the 12 week intervention period)
- Changes in brain neuroplasticity marker (with proton magnetic resonance spectroscopy)(Before and after the 12 week intervention period)
- Changes in balance (with posturography on Kistler platform)(Before and after the 12 week intervention period)
- Changes in rate of force development (with Biodex)(Before and after the 12 week intervention period)
- Changes in physical performance (with the Fitness Fullerton Test battery for the Senior)(Before and after the 12 week intervention period)
- Changes in subjective quality of life (patient reported outcome questionnaires)(Before and after the 12 week intervention period)
- Changes in nutrition (patient reported outcome questionnaires)(Before and after the 12 week intervention period)
研究者
Vilma Dudoniene
Associated professor
Lithuanian Sports University