Effect of the Addition of Medium Chain Triglycerides to a Mixed Macronutritional Meal on the Oxidation of Postprandial Macronutrients
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Post-prandial nutrient oxidation
研究概览
简要总结
The main aim of this study is to determine the effect of the addition of medium chain triglycerides to a mixed macro nutritional meal on postprandial macronutrients oxidation (i.e. fat oxidation, carbohydrate oxidation, change in respiratory quotient, peak respiratory quotient, etc.).
详细描述
A mixed meal characterized by a high quantity of carbohydrates could develop an increment in the postprandial carbohydrate oxidation. Medium chain triglycerides could be absorbed and metabolized immediately. It is plausible that its addition to a mixed meal unchains the decrement in the carbohydrate oxidation and increment in fat oxidation. If this hypothesis it is correct, its lower postprandial carbohydrate oxidation could develop a higher postprandial exposure to hyperglycemia, being of clinical interest.
20 young adults will be randomized into two conditions (experimental and control conditions) with 7 days of separation between conditions. Each evaluation day will conform to the following tests:
- Basal metabolic rate assessment through indirect calorimetry.
- Intake of the corresponding mixed meal (experimental or control)
- Postprandial nutrient oxidation and energy expenditure through indirect calorimetry
- Blood samples assessment in 9 time points during the evaluation day.
- Post-prandial sensations related to appetite in 11 time points during the evaluation day
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy male or female
- •Ages 18-30 years
- •BMI: 18-27.5 kg/m2
- •Stable weight over the last 3 months (body weight changes<35kg)
- •Participant must be capable and willing to provide consent, understand exclusion criteria, instructions and protocols.
排除标准
- •History of cardiovascular disease
- •Diabetes or hypertension
- •Pregnant, planning to become pregnant, or breastfeeding
- •Have been treated previously or during the study period with prescription drugs: antihypertensive, lipid lowering, acid uric lowering, glucose lowering, beta blockers or any drug that under the investigator's judged could influence the results.
- •Hematological pathology
- •Have had a blood transfusion or severe blood loss within the last 3 months
- •Allergy/intolerance to milk proteins, fish, soy, and/or any ingredient of the mixed meal
- •Any non-controlled medical condition which could influence results or could be worsened by the participation in the study
- •Claustrophobia
- •Needle phobia
- •Are deemed unsuitable by the investigator for any other reason, that prevent data collection.
结局指标
主要结局
Post-prandial nutrient oxidation
时间窗: 4 hours
Fat or carbohydrate oxidation measured by indrect calorimetry
次要结局
- Post-prandial sensations related to appetite(4 hours)
- Post-prandial blood insulin concentrations(4 hours)
- Post-prandial blood cholesterol concentrations(4 hours)
- Post-prandial blood lactate concentrations(4 hours)
- Post-prandial blood non-esterified fatty acid concentrations(4 hours)
- Post-prandial blood tryglicerides concentrations(4 hours)
- Post-prandial blood glycerol concentrations(4 hours)
- Post-prandial energy expenditure(4 hours)
- Post-prandial blood glucose concentrations(4 hours)
研究者
Jonatan Ruiz Ruiz
Associate professor
Universidad de Granada