The therapeutic effects of intermittent hypoxic breathing or exercise training on blood pressure and nitric oxide in hypertensive patients

Dapertment of physiology, Faculty of medicine, Khon Kaen University0 个研究点目标入组 63 人开始时间: 2018年2月20日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•1.Patients age between 30 to 59 years old;
•2.Patients with stage I hypertension (a blood pressure of at least 140/90 mm Hg and of unknown cause) diagnosed by medical specialists according to the JNC8 guidelines in spite of concurrent use of antihypertensive agents;
•3.Patients had to be under optimal medication treatment for at least six months;
•4.Patients had to be clinically stable (i.e. no crises or changes in medication) for at least three months.

•1.Patients have a serious respiratory disorder (e.g. asthma, COPD);
•2.Patients have a history of cardiovascular diseases (e.g. acute myocardial infarction, and/or unstable angina), history of heart failure and stroke;
•3.Patients presenting with history of neuromuscular and musculoskeletal diseases for more than one month;
•4.Patients have an uncontrolled serious medical disease (e.g. CKD stage III);
•5.Patients presenting with change of antihypertensive medication in the past 4 weeks before and during the experimental period;
•6.Patients presenting with endocrine disorders (e.g. hyperthyroidism, hypothyroidism);
•7.Woman in pregnancy and lactation;
•8.Patients had to be continuous exposure for more than one week to altitudes above 1,000 m during the three months preceding inclusion in the study;
•9.Patients who participate in the weight loss program or use of weight loss drugs;
•10. People with altitude sickness (e.g. bad headache, nausea, dizziness and feel exhausted) during the training sessions and cannot continue the experimental period;
•11. Patients who cannot participate in the intermittent hypoxic exposure or training continuously;
•12. People with psychology signs and symptoms (e.g. anxiety, depression).

发起方

Dapertment of physiology, Faculty of medicine, Khon Kaen University