Lidocaine Administration During Flexible Bronchoscopy and Endobronchial Ultrasound
试验速览
- 阶段
- 3 期
- 状态
- 终止
- 入组人数
- 29
- 试验地点
- 1
- 主要终点
- Cough
研究概览
简要总结
The purpose of this study is to assess if there is decrease in cough during flexible bronchoscopy and endobronchial ultrasound when different modes of lidocaine administration are used. The modes of administration being evaluated are topical, nebulized and atomized.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosis of mediastinal and/or hilar lymphadenopathy requiring endobronchial ultrasound evaluation and transbronchial needle aspiration.
- •Diagnosis of pulmonary disease requiring flexible bronchoscopy
- •Greater than 18 years of age.
排除标准
- •Any intervention beyond flexible bronchoscopy and endobronchial ultrasound
- •Inability to tolerate bronchoscopy.
- •Patients that receive paralytics.
- •Patients with neuromuscular diseases.
- •Inability to consent for procedures.
- •Allergies to lidocaine or any other drugs used in protocol.
- •Existing renal insufficiency or liver disease
研究组 & 干预措施
Topical Lidocaine
16 ml of 1% lidocaine sprayed in 4 ml aliquots to vocal cords, midtrachea, left main stem bronchus and right main stem bronchus.
干预措施: Topical lidocaine (Drug)
Nebuliser Solution
2% lidocaine dosed at 2mg/kg with max dose of 160mg nebulized via jet nebulizer in operating room over ten minutes.
干预措施: Nebuliser solution (Drug)
Nebuliser Suspension
2% lidocaine dosed at 2mg/kg with max dose of 160mg nebulized via vibrating mesh nebulizer in operating room over ten minutes.
干预措施: Nebuliser Suspension (Drug)
结局指标
主要结局
Cough
时间窗: 1 day
Number of coughs during procedure as defined by cough requiring stopping procedure or treatment by anesthesiologist with propofol or alfentanyl
次要结局
- Number of Participants With Post-Procedure Subjective Cough(1 day)
- Anesthesia Time to Wake up(1 day)
- Fentanyl Dosing(1 day)
- Alfentanyl Dosing(1 day)
- Propofol Dosing(1 day)
- Number of Participants With Post-procedure Sore Throat(1 day)
研究者
Jennifer Toth
Professor of Medicine and Surgery, Director of Interventional Pulmonology
Milton S. Hershey Medical Center