The Role of Two Nuclear Receptors for Oxysterols as a Molecular Cause of Uterine Dystocia: LXR Alpha and LXR Beta
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 58
- 试验地点
- 1
- 主要终点
- The multi-loci genotype of the target DNA sequence.
研究概览
简要总结
Despite the fact that a link between cholesterol and the myometrium has been clearly established, no study investigating aspects of cholesterol metabolism and uterine dystocia currently exists. This study is a pilot study whose aim is to test the hypothesis that an association between uterine dystocia and single-nucleotide polymorphisms (SNPs) in the genes coding for the LXRs.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing C-section for a dystocia: 2 to 3 hours of stagnation in labor progress are observed (ie no increasing dilation, and uterine contractions less that 3-5 per 10 minutes) in spite of measures taken to overcome dystocia (oxytocin injection and artificial breaking of waters)
- •the child is alive
- •the child does not have apriori known malformations that could interfere with a vaginal birth
- •foetus in cephalic position
- •full term pregnancy (>= 37 weeks of amenorrhea)
- •single birth
- •patient has signed consent
- •patient is affiliated with a social security system
排除标准
- •vaginal birth
- •programmed C-section
- •C-section is chosen because the fetus has a cardia rhythm problem, and there is no stagnation in the labor process
- •multiple pregnancy
- •the child is in a breech position
- •premature birth (<37 weeks amenorrhea)
- •in utero fetal death
- •fetal malformation known before birth that could interfere with a vaginal birth
- •non french-speaking patient (impossible to correctly inform the patient)
- •patient under guardianship
研究组 & 干预措施
Group 1
Control group: these patients have mechanical dystocia; cholesterol metabolism factors are a priori not involved.
干预措施: Whole blood sampling (Biological)
Group 2
These patients have uterine dystocia
干预措施: Whole blood sampling (Biological)
结局指标
主要结局
The multi-loci genotype of the target DNA sequence.
时间窗: Day 1
The polymorphisms of interest are the following SNPs: rs3758673, rs3758674, rs12221497, rs11039155, rs2279238, rs7120118, rs35463555, rs1052533, rs2248949, rs41432149, rs1405655, rs4802703.
次要结局
未报告次要终点