Effect of Ramosetron on Post-discharge Nausea and Vomiting in Patients Undergoing Gynecologic Surgery Through a Day-surgery Center
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- The change in the occurrence of postoperative vomiting
研究概览
简要总结
Nausea and vomiting after general anesthesia is one of the common anesthetic complications. If the patient is discharged from the hospital after surgery, proper treatment may be delayed or impossible if nausea or vomiting occurs. Thus, It is necessary to prevent these symptoms beforehand. Patients who underwent gynecologic surgery will be treated with prophylactic ramosetron to determine whether the frequency of nausea and vomiting is decreased when the patient returned home after discharge.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients who undergo hysteroscopic surgery and are discharged on the day of surgery.
排除标准
- •American Society of Anesthesiologists physical statue 3 or more
- •Planned admission after surgery
- •Intravenous anesthesia
- •During chemotherapy
- •Pregnancy or breastfeeding
- •Abnormal liver or kidney function
研究组 & 干预措施
Ramosetron
干预措施: Ramosetron (Drug)
Control
干预措施: Normal saline (Drug)
结局指标
主要结局
The change in the occurrence of postoperative vomiting
时间窗: Postoperative 30 minute, 3 hour, 24 hour, and 48 hour
The change in the occurrence of postoperative nausea
时间窗: Postoperative 30 minute, 3 hour, 24 hour, and 48 hour
次要结局
- The change in the number of postoperative administration of rescue antiemetic drug(Postoperative 30 minute and 3 hour)
- The change of patient's satisfaction score(Postoperative 30 minute, 3 hour, 24 hour, and 48 hour)
- The change of postoperative pain score(Postoperative 30 minute, 3 hour, 24 hour, and 48 hour)
- The change in the number of postoperative administration of rescue analgesic drug(Postoperative 30 minute and 3 hour)
研究者
Hyo-Seok Na
Principle investigator
Seoul National University Bundang Hospital