TOwards Prepared Mums (TOP-mums), for a Healthy Start: A Lifestyle Intervention to Reduce Overweight and Smoking in Women With a Pregnancy Wish to Prevent Perinatal Morbidity

简要总结

主要结局

次要结局

• HDL cholesterol of the child(At birth and 12 months postpartum)
• Respiratory rate of the child(Will be measured at 6 weeks and 12 months postpartum)
• Miscarriage(During pregnancy: at 6, 12 and 20 weeks of gestational age.)
• Gestational weight gain(6 weeks of gestational age to 36 weeks of gestational age)
• Delivery complications(At birth)
• Gamma-GT(Will be measured at baseline; Prepregnancy: after 3 months; During pregnancy: at 6, 20 and 32 weeks of gestational age; Postpartum: 3, 6 and 12 months.)
• ALAT(Will be measured at baseline; Prepregnancy: after 3 months; During pregnancy: at 6, 20 and 32 weeks of gestational age; Postpartum: 3, 6 and 12 months.)
• LDL cholesterol of the child(At birth and 12 months postpartum)
• Respiratory system resistance of the child(Will be measured at 6 weeks and 12 months postpartum)
• Fasting insulin level(Will be measured at baseline; Prepregnancy: after 3 months; During pregnancy: at 6, 20 and 32 weeks of gestational age; Postpartum: 3, 6 and 12 months.)
• Postpartum weight retention(6 weeks of gestational age to 6 months postpartum)
• Biochemical verification of tobacco use(Baseline. Prepregnancy: after 1, 2, 3, 6, 9 and 12 months. During pregnancy: at 6,12,20,32,36 and 40 weeks of gestational age. Postpartum: at 6 weeks and at 3, 6, 9 and 12 months.)
• Dietary habits(Baseline. Prepregnancy: after 3 and 12 months. During pregnancy: at 6 and 32 weeks of gestational age. Postpartum: 3 and 12 months.)
• Physical activity habits(Baseline. Prepregnancy: after 3 and 12 months. During pregnancy: at 6 and 32 weeks of gestational age. Postpartum: 3 and 12 months.)
• Vitamin D status(Will be measured at baseline and at 32 weeks of gestational age.)
• Dysmaturity and macrosomia(At birth)
• Smoking cessation(Baseline. Prepregnancy: after 1, 2, 3, 6, 9 and 12 months. During pregnancy: at 6,12,20,32,36 and 40 weeks of gestational age. Postpartum: at 6 weeks and at 3, 6, 9 and 12 months.)
• Insuline resistance (HOMA-IR)(Will be measured at baseline; Prepregnancy: after 3 months; During pregnancy: at 6, 20 and 32 weeks of gestational age; Postpartum: 3, 6 and 12 months.)
• Total cholesterol(Will be measured at baseline; Prepregnancy: after 3 months; During pregnancy: at 6, 20 and 32 weeks of gestational age; Postpartum: 3, 6 and 12 months.)
• Blood pressure(Will be measured at baseline; Prepregnancy: after 1, 2, 3, 6, 9 and 12 months; During pregnancy: at 6, 12, 20, 32, 36 and 40 weeks of gestational age; Postpartum: at 6 weeks and at 3, 6, 9 and 12 months.)
• Pulse wave velocity(Will be measured at baseline; Prepregnancy: after 3, 6 and 12 months; During pregnancy: at 6, 20 and 32 weeks of gestational age; Postpartum: at 6 and 12 months.)
• Time to pregnancy(From pregnancy wish to first day of last menstruation)
• Fasting glucose level(Will be measured at baseline; Prepregnancy: after 3 months; During pregnancy: at 6, 20 and 32 weeks of gestational age; Postpartum: 3, 6 and 12 months.)
• LDL cholesterol(Will be measured at baseline; Prepregnancy: after 3 months; During pregnancy: at 6, 20 and 32 weeks of gestational age; Postpartum: 3, 6 and 12 months.)
• HDL cholesterol(Will be measured at baseline; Prepregnancy: after 3 months; During pregnancy: at 6, 20 and 32 weeks of gestational age; Postpartum: 3, 6 and 12 months.)
• Free fatty acids(Will be measured at baseline; Prepregnancy: after 3 months; During pregnancy: at 6, 20 and 32 weeks of gestational age; Postpartum: 3, 6 and 12 months.)
• ASAT(Will be measured at baseline; Prepregnancy: after 3 months; During pregnancy: at 6, 20 and 32 weeks of gestational age; Postpartum: 3, 6 and 12 months.)
• Fat mass and fatt free mass(Will be measured at baseline, at 32 weeks of gestational age during pregnancy and 6 months postpartum)
• Fasting glucose level of the child(At birth and 12 months postpartum)
• Fasting insulin level of the child(At birth and 12 months postpartum)
• Pregnancy complications(At birth)
• Prematurity(At birth)
• Insulin resistance (HOMA-IR) of the child(At birth and 12 months postpartum)
• Total cholesterol of the child(At birth and 12 months postpartum)
• Triglycerides(Will be measured at baseline; Prepregnancy: after 3 months; During pregnancy: at 6, 20 and 32 weeks of gestational age; Postpartum: 3, 6 and 12 months.)
• Alkaline phosphatase(Will be measured at baseline; Prepregnancy: after 3 months; During pregnancy: at 6, 20 and 32 weeks of gestational age; Postpartum: 3, 6 and 12 months.)
• Tidal volume of the child(Will be measured at 6 weeks and 12 months postpartum)
• Respiratory system reactance of the child(Will be measured at 6 weeks and 12 months postpartum)
• Endothelial vasodilatation of the child: Percentage change between baseline and maximum perfusion nitroprusside(Will be measured at 6 weeks and 3 and 12 months postpartum)
• Triglycerides of the child(At birth and 12 months postpartum)
• Free fatty acids of the child(At birth and 12 months postpartum)
• Endothelial vasodilatation of the child: Percentage change between baseline and maximum perfusion acetylcholine(Will be measured at 6 weeks and 3 and 12 months postpartum)