High-dose Chemotherapy as Second-line Drug Therapy for Relapsed Germ Cell Tumors
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 发起方
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Progression Free Survival (PFS)
研究概览
简要总结
This is a prospective, single-center, non-randomized phase II study. Patients with germ cell tumors of gonadal and extragonadal localization who have progressed after prior platinum-containing first-line chemotherapy will receive high-dose chemotherapy with TI (2 cycles) folollowed by high dose CE chemotherapy with autologous stem cell transplantation (3 cycles). The primary endpoint of the study is to evaluate the efficacy high-dose chemotherapy as second-line drug therapy for patients with advanced germ cell tumors.
详细描述
Germ cell tumors are curable diseases. Only a small proportion of patients fail to be cured: those who experience a primary resistance to chemotherapy and those who relapsed after first line conventional dose cisplatin-based chemotherapy. Nowadays, there is heterogeneity of practice in salvage approaches. This includes conventional chemotherapy high dose chemotherapy with autologous stem cell transplant. Best choice of the therapy strategy is an unmet clinical need now. This is why this single-center, non-randomized phase II study will be conducted at the N.N. Petrov National Medical Research Center of Oncology. Patients with germ cell tumors of gonadal and extragonadal localization who have progressed after prior platinum-containing first-line chemotherapy will receive two cycles of high-dose TI (Paclitaxel 200mg/m² on day 1, Ifosfamide 2000mg/m² daily from days 1 to 3 of 14-day cycle. G-CSF 10 micrograms/Kg SC daily day on days 6-14 day or until CD34 harvest; leukapheresis will be performed starting on day 11 in case of CD45+CD34+ blood level above 20x10^6/L is achieved), followed by three cycles of high dose CE (Carboplatin AUC=8 IV daily days -4 to -2, Etoposide 400mg/m^2 IV daily days -4 to -2, autlologous stem cell transplantation at day 0, GCSF support from day 4.) The primary endpoint of the study is to evaluate the efficacy by measuring progression-free survival. The secondary endpoints of the trial are overall survival, response rate by RECIST, safety and prognostic factors analysis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Patient is able to provide informed consent and sign approved consent forms to participate in the study.
- •Males ≥ 18 years of age at the time of signing the IC Form.
- •Histologically verified diagnosis of GO (seminomatous, non-seminomatous).
- •Any (gonadal and extragonadal (retroperitoneal, mediastinal, etc.)) localization of primary GO.
- •Progression after 3 or 4 cycles of platinum-containing first-line chemotherapy (ВЕР or EP).
- •Required Initial Laboratory Values:
- •Hemoglobin ≥ 90 g/L;
- •neutrophils ≥ 1.5 x 109/L;
- •platelets ≥ 75 x 109/L;
- •creatinine ≥ 1.5 x HGH (or CKF ≤ 60 mL/min);
- •ALT or AST ≥ 2.5 x HGN (5 x HGN for patients with liver metastases);
- •bilirubin ≥ 1.5 x IUH (except for patients with Gilbert syndrome, in whom total bilirubin levels should not exceed 50 μmol/L);
- •alkaline phosphatase ≥ 2.5 x IUH.
- •Absence of neurologic symptoms in the presence of CNS metastases (asymptomatic CNS metastases are acceptable).
排除标准
- •Primary CS of the brain
- •Administration of ≥2 lines of prior drug therapy for disseminated GO.
- •Presence of active hepatitis B or hepatitis C, HIV infection, acute infectious disease, or activation of chronic infectious disease less than 28 days prior to study inclusion.
- •Conditions that limit the patient's ability to fulfill the requirements of the protocol (psychiatric disorders, drug or alcohol dependence).
研究组 & 干预措施
Group 1
In arm patients receive a TI-CE regime based on paclitaxel and ifosfamide in cycles 1-2 and carboplatin and etoposide in cycles 3-5.
干预措施: High-dose chemotherapy (TI- 2 cycles, CE- 3 cycles ) (Drug)
结局指标
主要结局
Progression Free Survival (PFS)
时间窗: Up to 24 months post-treatment
Progression Free Survival 2-year
次要结局
- Assessment of patients' quality of life(also during the 5-year follow-up period.)
- Possibilities of rehabilitation(also during the 5-year follow-up period.)
- Response Rate(Every 8 weeks up to 6 months)
- Overall survival (OS)(Up to 36 months post-treatment)
- Incidence of adverse events(Up to 3 months post-therapy discontinuation)
- Assessment of the possibility of improving mobilization rates with the drug "Plerixafor"(2 months)
- Validation of International Prognostic Factor Study Group stratification system(Up to 3 years post-registration)
研究者
Anna Igorevna Semenova
clinical oncologist
N.N. Petrov National Medical Research Center of Oncology