The Effect of Remote Ischemic Postconditioning on Liver Graft and Renal Function in Patients Undergoing Living-related Liver Transplantation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- total bilirubin
研究概览
简要总结
The investigators are trying to evaluate the clinical effect of remote ischemic postconditioning on liver graft function and postoperative renal function in subjects undergoing living-donor liver transplantation.
详细描述
Ischemic reperfusion injury of liver graft and postoperative renal dysfunction is a common problem which influence poor outcome in subjects undergoing liver transplantation. The incidence of postoperative renal dysfunction was reported as high as 12 ~ 64% and is thought to be caused by ischemia/reperfusion injury. Ischemic pre- or postconditioning was reported to be effective for preventing ischemia/reperfusion injury during liver transplantation. Remote ischemic pre- or postconditioning was also reported to be protective for ischemia/reperfusion injury in major organs in previous animal studies. Therefore, we are trying to evaluate the clinical effect of remote ischemic postconditioning on liver graft function and postoperative renal function in subjects undergoing living-donor liver transplantation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects undergoing living donor liver transplantation during the study period
- •Subjects older than 20 yrs who can give written informed consent
排除标准
- •Re-transplanted recipients
- •Those with peripheral vascular diseases affecting the extremities
- •Those with hepatic encephalopathy
- •Those with cirrhotic cardiomyopathy
结局指标
主要结局
total bilirubin
时间窗: before surgery and at 6, 12, 24, 36, 48, 60, 72, 84, 96 hours after the end of surgery
total bilirubin before surgery and at 6, 12, 24, 36, 48, 60, 72, 84, 96 hours after the end of surgery
次要结局
- Renal Function Test profiles(Before surgery and at 6, 12, 24, 36, 48, 60, 72, 84, 96 hours after the end of surgery)
- Liver Function Test Profiles(before surgery and at 6, 12, 24, 36, 48, 60, 72, 84, 96 hours after the end of surgery)
- incidence of Surgical Outcome(1 week, 1 month after the end of surgery)
- Length of hospital stay (days)(1 month, 2 month, 3 month after the end of surgery)
研究者
Jong Hwan Lee
Assistant Professor
Samsung Medical Center