Impact of Remote Ischemic Postconditioning on Autonomic Function and Prognosis in Clients With Acute Ischemic Stroke
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Ischemic Stroke
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
- Enrollment
- 150
- Locations
- 1
- Primary Endpoint
- Heart Rate Variabilities
- Last Updated
- 8 years ago
Overview
Brief Summary
The purpose of this study is to determine whether remote ischemic postconditioning (RIPostC) initiates autonomic nervous system response and affects the prognosis in patients with acute ischemic stroke.
Detailed Description
Remote ischemic postconditioning (RIPostC) has proven effective in reducing the ischemia-reperfusion injury. But the defensive mechanism of RIPostC still unclear. Stroke is frequently associated with autonomic dysfunction. Heart rate variability (HRV) represents the autonomic nervous system activity.This study aims to investigate whether RIPostC correlates with autonomic function and thus predicts prognosis of stroke.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Diagnosed as ischemic stroke according to the Chinese guideline of diagnosis and treatment of acute ischemic stroke 2010
- •Age between 18 to 85 years old
- •initial ischemic stroke within 14 days or less.
- •National Institutes of Health Stroke Scale (NIHSS)score 0-15
- •Modified Rankin Scale(mRS)score 1-4
- •Informed consent
Exclusion Criteria
- •Intravenous or arterial thrombolysis, or revascularization
- •Acute myocardial infarction,atrial fibrillation,arrhythmia,or cardiogenic cerebral embolism
- •Systolic Blood Pressure(SBP)\>200mmHg after medication treatment
- •Plasma fibrinogen\>7g/L
- •Upper limb fracture or percutaneous injury
- •Subclavian artery stenosis
- •With severe cardiac,respiratory,hepatic,and renal dysfunction or malignant tumor
- •Simultaneous participation in another interventional study
Outcomes
Primary Outcomes
Heart Rate Variabilities
Time Frame: at the time points of baseline and 7 and 30 days after treatments
Heart rate variability (HRV) is one of the most promising markers represent for autonomic function.We assess the changes from baseline heart rate variability to 7days and 30days.
Secondary Outcomes
- National Institutes of Health Stroke Scale(NIHSS)(at the time points of baseline and 7days after treatments.)
- Modified Rankin scale(mRS)(at the time points of baseline and 7,30 and 90 days after treatments)
- Barthel Index(BI)(at the time points of baseline and 7,30 and 90 days after treatments)