A Randomized, Controlled Double Blind Acute Study: Effects of Protein Blends on Muscle Protein Synthesis and Breakdown in Healthy Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Fractional Synthetic Rate (Muscle Protein Synthesis)
研究概览
简要总结
During aging there is a tendency for muscle protein synthesis (growth) to become less efficient and the resulting consequence leads to reduced muscle mass (sarcopenia) which can affect strength and mobility. Protein consumption may be one opportunity to alleviate this problem especially when consumed in appropriate amounts following resistance training. This study is designed to determine if a soy dairy protein blend, shown to be effective in younger adults, will produce beneficial muscle protein synthesis in older healthy adults following resistance exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 55 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •55-70 yr olds Stable Body weight
排除标准
- •Exercise training (>2 weekly sessions of moderate to high intensity aerobic or resistance exercise)
- •Significant heart, liver, kidney, blood, respiratory disease or thyroid issues
- •Peripheral vascular disease
- •Orthopedic injury that prohibits participation in the exercise training
- •Diabetes mellitus or other untreated endocrine disease
- •Active cancer (all groups) and history of cancer
- •Acute infectious disease or history of chronic infections (e.g. TB, hepatitis, HIV, herpes)
- •Neurologic Injury or disease
- •Recent (within 6 months) treatment with anabolic steroids, or corticosteroids.
- •Alcohol or drug abuse
- •Tobacco use (smoking or chewing)
- •Malnutrition (BMI < 20 kg/m2, hypoalbuminemia, and/or hypotransferrinemia)
- •Obesity (BMI > 30 kg/m2)
- •Low hemoglobin levels (below normal values)
- •Food allergies
- •Taking dietary supplements such as green tea, omega 3 fatty acids, etc.
研究组 & 干预措施
Soy Dairy Protein Blend
30 grams of Soy Dairy Protein Blend given as a single beverage following leg resistance exercise
干预措施: Soy Dairy Protein Blend (Dietary Supplement)
Positive Control (Dairy Whey Protein)
30 grams of Dairy Whey Protein will be given as a single beverage following leg resistance exercise
干预措施: Positive Control (Dairy Whey Protein) (Dietary Supplement)
结局指标
主要结局
Fractional Synthetic Rate (Muscle Protein Synthesis)
时间窗: baseline, 3 hrs, 5 hrs
The fractional synthesis rate (FSR) of mixed muscle proteins will be calculated from the incorporation rate of L-\[ring-13C6\]Phenylalanine into the mixed muscle proteins, and the free-tissue phenylalanine enrichment.
次要结局
- Anti-inflammatory and Anti-oxidant Markers(baseline, 3 hrs, 5 hrs)
- Intracellular Signalling Genes and Proteins(baseline, 3 hrs, 5 hrs)