ACTRN12609001074280招募中未知
Interactions between oral and small intestinal exposure to oleic acid: effects on antropyloroduodenal pressures, gut peptide and oleoylethanolamine (OEA) release, serum triglyceride concentrations, appetite and energy intake in healthy lean and obese participants.
Dr Tanya Little0 个研究点目标入组 30 人开始时间: 2009年12月15日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 发起方
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Prevention
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 55 Years（—）
- 性别
- All
入选标准
- •Equal numbers of healthy male and female subjects, 15 of normal body weight for their height (body mass index (BMI): 19 - 25 kg/m2), and 15 obese (BMI 30 – 35 kg/m2), aged 18-55 years. Subjects will need to be unrestrained eaters, non-smokers, and for female subjects will be required to be taking an appropriate hormonal contraceptive.
排除标准
- •(1)significant gastrointestinal symptoms; disease or surgery
- •(2)current use of prescribed or non-prescribed medications (including vitamins and herbal supplements) which may affect energy metabolism, GI function, body weight or appetite (e.g. domperidone and cisapride, anticholinergic drugs (e.g. atropine), metoclopramide, erythromycin, hyoscine, orlistat, green tea extracts, Astragalus, St John's Wort etc.)
- •(3)diabetes mellitus
- •(4)epilepsy
- •(5)cardiovascular or respiratory disease
- •(6)any other significant illness as assessed by the investigator
- •(7)allergy to local anaesthetic
- •(8)intake of > 20 g alcohol on a daily basis
- •(9)smokers (cigarettes, cigars, marijuana)
- •(10)in female subjects, pregnancy or lactation. A pregnancy test will be performed in all female subjects, using a urine sample, prior to commencement of the study and subsequently prior to each study day
- •(11)restrained eaters, as determined by a score of >12 on the eating restraint questionnaire component of the eating questionnaire (35). However, while the degree of eating restraint will be assessed and recorded in the obese subjects, this will not be used as an exclusion criteria, as the majority of obese subjects are likely to have some degree of eating restraint.
- •(12)donation of blood in the 12 weeks prior to enrolment in the study. Subjects will also be instructed to abstain from donating blood for 12 weeks after study completion
- •(13)low iron levels
- •(14)consumption of a vegetarian diet
研究者
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