Measurement of Stress Symptom in Students During Long-term Pharmacy Practices and Evaluation of Anti-stress Effect of Theanine Consumption on Students
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Alterations in salivary amylase activity in students with pharmacy practices
研究概览
简要总结
Long-term practices in a hospital setting and community pharmacy might induce chronic stress in students. Alterations of salivary amylase activity will be measured in students during pharmacy practices as a marker of stress. Theanine is reported to have anti-stress effect on experimental animals under chronic stress and on humans under short-term stress. The purpose of this study is to measure stress symptoms in students during long-term pharmacy practices and to evaluate the efficacy of theanine in suppressing chronic stress, by measuring the salivary amylase activity.
详细描述
The investigators have found that theanine, an amino acid in green tea, has anti-stress and anti-aging effects using experimental animals. Mice, under chronic psychosocial stress, showed shortened longevity and brain dysfunction. However, when the mice ingested theanine, they showed normal longevity and brain function even though the mice were under psychosocial stress. These data showed that theanine has a significant anti-stress effect on mice. In addition, theanine has been reported to have an anti-stress effect on humans against short-term stress by measuring salivary amylase activity. However, the efficacy of theanine against chronic stress has not been examined. Long-term pharmacy practices might induce chronic stress in students. Based on this background, the investigators designed a randomized study to evaluate the clinical efficacy of theanine ingestion in suppressing chronic stress in students during long-term pharmacy practices.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 22 Months 至 30 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Students of pharmaceutical sciences in the fifth grade, nonsmoker
- •Obtained written informed consent from the student before participation
- •Possible to take tablets for 16 days
- •Possible to check salivary amylase activity two times daily for 10 days
排除标准
- •Taking tranquilizer(s)
- •Diagnosed as inadequate to participate in the study by a doctor
结局指标
主要结局
Alterations in salivary amylase activity in students with pharmacy practices
时间窗: 10 days
次要结局
- Numbers of students deteriorated physical condition(10 days)
- Incidence of days of coming late or leaving early(10 days)
- Alterations in sleeping hours from baseline(10 days)
- Alterations in the response to a stress questionnaire from baseline(10 days)