Impact of Transcranial Direct Current Stimulation of the Motor Cortex on Language Functions in Residual Aphasia
试验速览
- 阶段
- 不适用
- 入组人数
- 16
- 试验地点
- 2
- 主要终点
- Response latency during picture naming task (max. 80)
研究概览
简要总结
The present study assesses whether language functions in patients with residual post-stroke aphasia can be improved by transcranial direct current stimulation administered to the primary motor cortex in the language dominant (left) hemisphere.
详细描述
Patients will participate in two tDCS sessions (atDCS; sham) in a cross-over within subjects design. tDCS or placebo will be administered during simulatneous fMRI to assess neural signatures of the stimulation. Order of stimulation will be counterbalanced between subjects
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •right handedness
- •German native speaker
- •cerebrovascular stroke in left hemisphere (>6 months)
- •mild aphasia (according to Aachen Aphasia Test Battery Classification, Huber et al., 1983)
- •residual anomia in naming test (>75 correct responses)
排除标准
- •other current or previous neurological or psychiatric diseases
- •alcohol or drug abuse
- •MRI contraindication (e.g. magnetic metal, pacemaker, claustrophobia)
结局指标
主要结局
Response latency during picture naming task (max. 80)
时间窗: Change in response latency between assessment 1 (week 1) and assessment 2 (week 2), assessments 1 and 2 are seperated by one week
Subjects are assessed in a cross-over design. The primary outcome measure will be assessed twice in each subject, either during placebo ("sham) stimulation or active (anodal) stimulation with transcranial direct current stimulation. Order of stimulation will be counterbalanced across the group.
次要结局
- Change in neural activity measured by functional magnetic resonance imaging(Change in fMRI activity between Assessment 1 (week 1) and Assessment 2 (week 2), assessments 1 and 2 are seperated by one week)
研究者
Marcus Meinzer
Creutzfeldt Fellow
Charite University, Berlin, Germany