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临床试验/NCT04439981
NCT04439981已完成不适用

Beneficial Effect of Curcuma Extract In Muscle Damage (Study in Soccer Athlete): Randomized Clinical Trial

Universitas Muhammadiyah Semarang2 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2019年4月8日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
20
试验地点
2
主要终点
Hemoglobin change

研究概览

简要总结

Muscle damage and inflammation is a clinical problem caused by the unimpeachable body adaptation of strenuous exercise through increasing free radicals. Antioxidants content in Curcuma is hypothesized to alleviate the free radicals. This study aimed to examine the effect of Curcuma extract in the form of ice cream to improve muscle damage and inflammation of soccer athletes caused by strenuous exercise. This study was experimental study with pre-post control group design. Male soccer athlete (n=20) were divided into treatment group (n=10) and control group (n=10). The treatment group was treated by Curcuma extract ice cream for 21 days. Blood samples of creatine kinase (as muscle damage marker) and IL-6 (as inflammation marker) were quantified.

详细描述

Muscle damage is a clinical problem caused by the adaptation process in strenuous exercise of soccer athletes which free radical is the main culprit of the damage. There is a significant increment of muscle damage after strength exercise using leg press. Physical exercise leads to inflammation process in endothelial cells of blood vessel which can be marked by releasing cytokine. Interleukin-6 (IL-6) is one of cytokine pro-inflammation and this marker is used as an indicator for inflammation of micro-trauma in muscle during strenuous exercise.

Normally, free radical generation will be stabilized by endogenous antioxidant secretion such as superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase; nevertheless, body needs exogenous antioxidant to support endogenous antioxidant as a scavenger of free radical in such condition.

Muscle damage due to the strenuous exercise should be managed to avoid the pain feeling and subsequently decrease athlete performances. Some previous studies used herbs such as ginger (Zingiber officinale), ginseng (Panax quinquefolium), and Curcuma to relieve the muscle damage and inflammation resulting from high-intensity exercise.The Curcuma extract treatment to the athlete gained lack of success; therefore, supplementation to food products might use to increase acceptability. Ice cream is one of the products, which has a broad segment market and every single person regardless of age is fond of it.

Curcumin is an antioxidant substance contained in Curcuma and it has better antioxidant capacity compared to the other component in Curcuma such as demetoksicurcumin and bisdemetoksicurcumin.Besides, curcumin has an efficient reaction with superoxide radicals as well as lipid antioxidants has, and the reaction leads to superoxide catalytic degradation in which curcumin represents as a superoxide dismutase. This study aimed to examine the Curcuma extract effect which has been supplemented to own-made ice cream in muscle damage and inflammation of soccer athletes after having strenuous exercise.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
14 Years 至 18 Years(Child, Adult)
性别
Male
接受健康志愿者

入选标准

  • 14-18 year-old
  • does not have an acute and chronic
  • hemoglobin level ≥13 g/L
  • nutrition status normal (BMI >18.5-25.0)
  • no coffee consumption
  • no alcohol consumption
  • no drugs consumption
  • no smoking
  • no vitamin and other supplements consumption at least two weeks before this study was conducted
  • no additional exercise except the programmed exercise

排除标准

  • Subject did not comply the procedure of the study

结局指标

主要结局

Hemoglobin change

时间窗: 21 days

Change from baseline hemoglobin at 21 days taken in the lab from venous blood specimen using cyanmethemoglobin method

Lactic acid change

时间窗: 21 days

Change from baseline lactic acid at 21 days taken in the lab from venous blood specimen using spectrophotometric method

IL-6 change

时间窗: 21 days

Change from baseline IL-6 at 21 days taken in the lab from venous blood specimen using ELISA method

Creatinine kinase change

时间窗: 21 days

Change from baseline creatinine kinase at 21 days taken in the lab from venous blood specimen using ELISA method

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Ali Rosidi, Dr

Dean of Faculty of Nursing and Health, Universitas Muhammadiyah Semarang

Universitas Muhammadiyah Semarang

研究点 (2)

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