Phase 4 Study of Desflurane and Sevoflurane That Affect Pulmonary Mechanics During Minimally Invasive Repair of Pectus Excavatum
试验速览
- 阶段
- 4 期
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- pulmonary mechanics
研究概览
简要总结
The aim of the current study was to compare the effects of sevoflurane and desflurane on respiratory mechanics in patients undergoing repair of pectus excavatum.
详细描述
The minimally invasive technique for pectus excavatum repair was introduced by Nuss and colleagues using a metal bar to lift the depressed chest wall. This surgical procedure is usually done under general anesthesia with tracheal intubation. After inserting metal bar into the chest wall, decreased lung compliance was shown. Previous studies demonstrated that administering desflurane during anesthesia resulted in marked increases in respiratory mechanical parameters, especially in the children with airway susceptibility. Our primary hypothesis was that desflurane would cause an increase in respiratory resistance and a decrease in lung compliance compared to sevoflurane during repair of pectus excavatum.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 15 Years 至 —(Child, Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •clinical diagnosis of Pectus Excavatum
- •undergoing minimally invasive repair
排除标准
- •younger than 15 year old
- •history of upper respiratory tract infection within recent 2 weeks
- •chronic obstructive pulmonary disease
- •previous treatment with bronchoactive drugs (B-agonist or antagonist, theophyline, anticholinergics and corticosteroid)
- •history of neurological deficits
研究组 & 干预措施
sevoflurane
Anesthesia with sevoflurane
干预措施: Sevoflurane (Drug)
Desflurane
Anesthesia with desflurane
干预措施: Desflurane (Drug)
结局指标
主要结局
pulmonary mechanics
时间窗: within the 2 hours during the surgery
respiratory resistance dynamic and static lung compliance
次要结局
- complication(within 72 hours after sugery)
研究者
Jeong Eun Kim
Clinical Assistant Professor
The Catholic University of Korea
