Dual renin-angiotensin system-blockade by angiotension-converting enzyme-inhibition and angiotension receptor type 1 receptor blockade, role of the angiotension-converting enzyme inhibitor or D genotype and low sodium diet in non-diabetic proteinuric patients

niversity Medical Center Groningen (UMCG) (The Netherlands)0 个研究点目标入组 56 人开始时间: 2006年6月29日最近更新: 2015年1月13日

适应症

试验速览

暂无简介。

•1. Older than 18 years of age
•2. Chronic non-diabetic renal disease, as established by history, urine analysis, serum biochemistry tests and/or renal biopsy
•3. Creatinine clearance >30 ml/min/1.73 m
•4. Residual proteinuria >1 g per 24 hours

•1. Failure to meet the above inclusion criteria
•2. Diabetes mellitus
•3. Any contra-indication to the use of ACE inhibitors or AT1 receptor blockers
•4. A history of myocardial infarction, unstable angina, coronary bypass or cardiovascular accident (CVA) during the past six months
•5. Heart failure New York Heath Association (NYHA) class III-IV
•6. High rate of renal function loss (decline in creatinine clearance >6 ml/min/1.73 m^2 during the past year)
•7. Need for treatment with corticosteroids, non-steroidal anti-inflammatory drugs (NSAIDs) or immunosuppressive drugs
•8. Proteinuria >10 g per 24 hours and hypoalbuminaemia <28 g/l
•9. Renovascular hypertension, malignant hypertension (diastolic blood pressure >100 mmHg)
•10. Serum potassium >6 mmol/l

发起方

niversity Medical Center Groningen (UMCG) (The Netherlands)