Efficacy of Acetaminophen-ibuprofen Combination on the Postoperative Pain After Thyroidectomy
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- postoperative pain
研究概览
简要总结
Acetaminophen and ibuprofen has been safely used for a long time and reduces postoperative pain and opioid dosages. Investigators are planning to compare the efficacy of 1) acetaminophen only and 2) acetaminophen and ibuprofen combination at postoperative pain after thyroidectomy.
详细描述
Acetaminophen and ibuprofen has been safely used for a long time and reduces postoperative pain and opioid dosages. Investigators are planning to compare the efficacy of 1) acetaminophen 1g only and 2) the combination of acetaminophen 1g and ibuprofen 300mg at postoperative pain after thyroidectomy. Some recovery valuables such as the postoperative pain and opioid requirements will be assessed
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •the patients undergoing scheduled thyroidectomy
- •American Society of Anesthesiologists status 1 or 2
排除标准
- •refusal to be enrolled in the study
- •emergency surgery
- •hepatic or renal disease
- •on chronic pain medications
- •psychiatric disorders
- •pregnancy, lactation
- •allergy or contraindication to the study drug
研究组 & 干预措施
control group
acetaminophen 1g iv dripping
干预措施: Acetaminophen (Drug)
experimental group
the combination of acetaminophen 1g and ibuprofen 300mg iv dripping
干预措施: Acetaminophen (Drug)
experimental group
the combination of acetaminophen 1g and ibuprofen 300mg iv dripping
干预措施: Ibuprofen (Drug)
结局指标
主要结局
postoperative pain
时间窗: during 30 minutes after surgery
the maximal postoperative pain severity using pain scale(visual analogue scale; 0 cm=no pain; 10 cm=the worst pain)
次要结局
- pain killer requirement(during 30 minutes after surgery)
研究者
Young Eun Moon
professor
The Catholic University of Korea