Covariates of Coronary Artery Plaque Burden and Composition by CT Coronary Angiography in Women and Men With Stable Angina and Non-obstructive Coronary Artery Disease - Analysis From the NORIC Registry
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 1,400
- 试验地点
- 1
- 主要终点
- Cardiovascular mortality and nonfatal acute myocardial infarction
研究概览
简要总结
Non-obstructive coronary artery disease (CAD), particularly common in women, has been associated with impaired quality of life and risk of recurrent hospitalizations. Several studies have also demonstrated increased risk of incident acute coronary events and mortality.
The main objective of the project is to assess the association between coronary artery plaque features by coronary CT angiography and long term prognosis in a large unselected population undergoing CT coronary angiography due to stable angina and suspected myocardial ischemia from the Norwegian Registry for Invasive Cardiology (NORIC) diagnosed with non-obstructive CAD by coronary CT angiography.
详细描述
Patients with stable angina and non-obstructive coronary artery disease by CT coronary angiography will be selected from the Norwegian Registry of Invasive Cardiology (NORIC). This is a national quality control registry run and controlled by the Norwegian Institute of Public Health (www.fhi.no). All CT coronary angiograms will be reanalyzed using advanced post-processing analysis software to assess coronary artery plaque burden, distribution and composition. Through linking with the Norwegian Cardiovascular Disease Registry and the Cause of Death Registry (www.fhi.no) we will be able to assess the association between long-term prognosis (5 years) and coronary artery plaque features.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Stable angina
- •Non-obstructive coronary artery disease by CT coronary angiography defined as <50% stenosis (lumen diameter reduction)
排除标准
- •Obstructive coronary artery disease
- •Unstable angina
- •Previous myocardial infarction, heart surgery or percutaneous coronary interventions
结局指标
主要结局
Cardiovascular mortality and nonfatal acute myocardial infarction
时间窗: 5 years
Composite of deaths caused by cardiovascular disease and nonfatal acute myocardial infarction
次要结局
- All-cause mortality, hospitalization due to cardiovascular disease and revascularization procedures(5 years)
研究者
Mai Tone Lønnebakken
Professor
University of Bergen