The Association Between Decentering and Reductions in Relapse/Recurrence in Mindfulness-Based Cognitive Therapy for Depression in Adults: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 227
- 试验地点
- 2
- 主要终点
- Major depressive disorder (MDD) relapse/recurrence - incidence of
研究概览
简要总结
Objective: "Decentering" is defined as the ability to observe one's thoughts and feelings as temporary, objective events in the mind, and is increasingly regarded as a candidate mechanism in mindfulness-based interventions. The current study sought to examine the role of decentering, and other related variables, in the efficacy of Mindfulness-based cognitive therapy (MBCT) as compared to two active comparison conditions.
Method: Formerly depressed individuals (N = 227), randomly assigned to MBCT (n = 74), relaxation group therapy (RGT; n = 77) or treatment-as-usual (TAU; n = 76), completed self-report measures of decentering and symptoms of depression at pre-, mid-, and post-treatment, and relapse was assessed at 3, 6, 9, and 12 months, post-treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •a Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM IV-TR; American Psychiatric Association (APA), diagnosis of major depressive disorder (MDD) without psychotic features, in Full Remission;
- •three or more prior major depressive episodes;
- •age between 18 and 65 years;
- •cognitive reactivity (CR) or mood-activated dysfunctional beliefs score greater than or equal to eight (see assessment procedure below);
- •a score of less than 10 on the Hamilton Rating Scale for Depression (HRSD);
- •minimum of a 10 week period free of psychotropic medication other than stable dosage of antidepressant medication for a minimum of four weeks;
- •fluency in English; An increased cognitive reactivity score of eight points or more and,
- •ability to give informed consent and complete questionnaires unassisted.
排除标准
- •a diagnosis of bipolar disorder (past or present), schizophreniform disorders, substance abuse or dependence (current or within the past six months), borderline or antisocial personality disorder, or neurocognitive disorders;
- •current psychotherapy or counselling more frequently than twice per month;
- •current practice of meditation more than once per week or yoga more than twice per week;
- •electroconvulsive therapy within the past six months; or
- •self-reported ingestion of alcohol or other psychoactive substances within the past 48 hrs.
结局指标
主要结局
Major depressive disorder (MDD) relapse/recurrence - incidence of
时间窗: 12- month post-treatment follow-up
Number of participants meeting criteria for relapse/recurrence of MDD during follow-up
Change in major depressive disorder (MDD) relapse/recurrence - time to relapse/recurrence
时间窗: 3-, 6-, 9-, and 12- month post-treatment follow-up
Change in relapse/recurrence of MDD (i.e., survival) across follow-up
次要结局
- Change in Beck Depression Inventory - Second Edition total scores(Pre-, mid- (i.e., at week 4 of MBCT), and post-treatment (i.e., after 8 weeks of MBCT))
研究者
Mark Lau
Principle Investigator
University of British Columbia