The Effect of Curcumin Supplementation on Anthropometric Indices, Insulin Resistance and Oxidative Stress in Patients With Type 2 Diabetes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 44
- 试验地点
- 2
- 主要终点
- Insulin
研究概览
简要总结
Diabetes mellitus is the most common endocrine disorder, causes many complications such as micro- and macro-vascular diseases. Various kinds of antidiabetic drugs have been developed, but most of them have side effects. Recently, the use of natural plant products has gained more attention among scientists in order to prevent diabetic vascular complications. Curcumin is a natural yellow product derived from the turmeric rhizome which has shown to be non-toxic and exhibits various bio¬logical activities such as anti-oxidant, anti-inflammatory, anti-carcinogenic, and anti-diabetic effects. Curcumin is effective in reducing glycemic index and hyperlipidemia in rodent models and is relatively inexpensive and safe. Most of the studies conducted on animal model, and just a few of them are on human model. The present study was planned to evaluate the effects of curcumin supplementation The effect of curcumin supplementation on anthropometric indices, insulin resistance and oxidative stress in patients with type 2 diabetes
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 40 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •insulin Inclusion Criteria:
- •a) Tendency to participate b) Age range of 40-65 c) Suffering from diabetes type 2 ( between 1 to 10 yeares) d) BMI 18/5-30 e) Patients with diabetes who administer oral hypoglycemic agents and do not use
排除标准
- •a) patients with liver diseases b) patients with kidney diseases c) patients with inflammatory diseases d) patients with liver diseases e) Administering herbal agents f) Administering multivitamins and minerals in past 3 months
研究组 & 干预措施
control
placebo
干预措施: Placebo (Dietary Supplement)
intervention
500 mg curcumin capsule
干预措施: Curcumin (Dietary Supplement)
结局指标
主要结局
Insulin
时间窗: 10 week
HbA1c
时间窗: 10 week
fasting blood sugar
时间窗: 10 weeks
Homeostatic Model Assessment of Insulin Resistance
时间窗: 10 week
Change in pancreatic B-cell function
时间窗: 10 week
次要结局
- total capacity antioxidant(10 weeks)
- Malondialdehyde(10 week)
- Body mass index(10 week)
- Waist circumference(10 week)
研究者
Dr Azita Hekmatdoost
Principal Investigator
National Nutrition and Food Technology Institute