Effectiveness of Heliox in Hypercapnic Respiratory Failure

East Kent Hospital Trust0 个研究点目标入组 68 人开始时间: 2008年6月27日最近更新: 2019年12月10日

试验速览

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•1. All patients with hypercapnic respiratory failure due to exacerbations of COPD admitted to A&E/ CDU at the William Harvey Hospital will be considered for the study.
•Patients therefore need to be
•1)Acidotic ( arterial blood gas pH < 7.35) due to high blood carbon dioxide
•2)Have a formal diagnosis of COPD
•3)Be admitted with an exacerbation of COPD
•4) PO2 < 8kpa
•5) PCO2 > 7kpa
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•1) Patients deemed not competent to make a decision about consent for the study by the admitting doctor based on Abbreviated Mental Test Score < 7 out of 10
•2) Patients who are comatose / drowsy on admission and unable to communicate
•3) Patients requiring immediate NIV or Intubation at time of assessment by member of research team / Medical Registrar. ( In some situations patients may have had delay in assessment by A&E staff or have received controlled oxygen therapy by paramedics . If these patients are deteriorating when assessed they will be excluded and started on immediate NIV)
•4) Have hypercapnic respiratory failure for a reason other than COPD exacerbation
•5) Do not understand verbal/ written information in English

发起方

East Kent Hospital Trust