Ultrasound Evaluations of Diaphragm and Intercostal Muscle to Predict the Failure of High-Flow Nasal Cannula Therapy
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Ultrasound evaluation of diaphragm
研究概览
简要总结
The study aims to predict the failure of High-flow Nasal Cannula oxygenation therapy by ultrasound evaluation of diaphragm and intercostal muscle contraction during the first 24 hours.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •more than 18 years old
- •needing High-flow Nasal Cannula oxygenation therapy
排除标准
- •received mechanical ventilation, including invasive or noninvasive ventilation within one month prior to enrollment
- •history of neuromuscular disorders (e.g., myasthenia gravis, Guillain-Barre syndrome);
- •immediate endotracheal intubation is required (life-threatening hypoxemia)
- •extensive damage to the thoracic skin (e.g., burns) unable to undergo ultrasonography
- •pregnancy
- •attending physician deemed it inappropriate to participate in the trial.
结局指标
主要结局
Ultrasound evaluation of diaphragm
时间窗: Six times a day by the 0,2,6,12,18,24 hours following initiation of High-flow Nasal Cannula (HFNC)oxygenation treatment.
Thickness of the diaphragmatic muscle and the diaphragm thickening fraction (DTF) by ultrasound evaluation
The patient's condition deteriorated and required noninvasive or intubated invasive mechanical ventilation.
时间窗: up to 30 days after High-flow Nasal Cannula (HFNC)oxygenation therapy.
Failing or not failing HFNC, the rate of needing noninvasive or intubated invasive mechanical ventilation.
Ultrasound evaluation of intercostal muscle movement index
时间窗: Six times a day by the 0,2,6,12,18,24 hours following initiation of High-flow Nasal Cannula (HFNC)oxygenation treatment.
the parasternal intercostal muscles thickening fraction by ultrasound evaluation
次要结局
- ICU stay(up to one month after High-flow Nasal Cannula (HFNC)oxygenation therapy.)
- all cause mortality(up to one month after High-flow Nasal Cannula (HFNC)oxygenation therapy.)
- VT(Six times a day by the 0,2,6,12,18,24 hours following initiation of High-flow Nasal Cannula (HFNC)oxygenation treatment.)
- duration on HFNC(up to one month)
- Hospital stay(up to one month after High-flow Nasal Cannula (HFNC)oxygenation therapy.)
- respiratory rate(Six times a day by the 0,2,6,12,18,24 hours following initiation of High-flow Nasal Cannula (HFNC)oxygenation treatment.)
- Oxygen saturation(Six times a day by the 0,2,6,12,18,24 hours following initiation of High-flow Nasal Cannula (HFNC)oxygenation treatment.)
- oxygen concentration(Six times a day by the 0,2,6,12,18,24 hours following initiation of High-flow Nasal Cannula (HFNC)oxygenation treatment.)
- flow velocity of HFNC(Six times a day by the 0,2,6,12,18,24 hours following initiation of High-flow Nasal Cannula (HFNC)oxygenation treatment.)