Identification of Specific Molecular Signatures by Capture-HPV and Next-generation Sequencing in HPV-induced Oropharyngeal Cancers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- Description the HPV molecular signatures identified by the Capture-HPV technique and comparison of these signatures with those already described in the classification described in the Holmes et al. in the cervix
研究概览
简要总结
The aim of this study is to identify HPV molecular signature in head and neck cancer to establish a new classification for positive human papillomavirus oropharyngeal tumor
详细描述
OROPAP is a monocentric exploratory study with retrospective inclusion of patients.
The retrospective study focus on patients who have had surgery for HPV-positive oropharyngeal tumors whose survival is at least 2 year.
Frozen and or FFPE biopsies of these tumors and frozen blood samples are available via the HEGP biological resources platform.
The HPV molecular signatures will be identified by the capture-HPV technique.
For each patient, clinical-anatomo-pathological data such as tumor size, tumor stage, presence or absence of metastasis, histological stage, different treatment lines and 2-years survival data will be collected through the use of data warehouse available on the HEGP.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with HPV + oropharyngeal cancer
排除标准
- 未提供
结局指标
主要结局
Description the HPV molecular signatures identified by the Capture-HPV technique and comparison of these signatures with those already described in the classification described in the Holmes et al. in the cervix
时间窗: 18 months
Establish a new classification based on HPV molecular signature for positive human papillomavirus oropharyngeal tumor
次要结局
- Correlate identified HPV molecular signature with clinical-anatomo-pathological data.(18 months)
- Description of new HPV viral variants based on complete HPV genome sequencec obtained by Capture-HPV coupled with NGS(18 months)
- Quantification of HPV circulating tumoral DNA in peripheral blood by droplet based digital PCR(18 months)
- Number of Death of any cause, or eventual relapse(18 months)
- Ratio of the number of copies of viral genes to the number of cells(18 months)
- Precise description of HPV insertion localisation in human genome when HPV is integrated(18 months)