ISRCTN52480460已完成未知
Cardiac computed tomography (CT) for the Assessment of chest Pain and Plaque: a randomised controlled trial
lster Hospital (UK)0 个研究点目标入组 500 人开始时间: 2010年9月7日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 500
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 性别
- All
入选标准
- •1. Patients over 40 referred to the Rapid Access Chest Pain Clinic (RACPC), Ulster Hospital, Northern Ireland for suspicion of angina
- •2. Patients must have the ability to hold breath
排除标准
- •1. Less than 40 years of age
- •2. Significant renal dysfunction with an estimated Glomerular Filtration Rate (eGFR) less than 35. As the contrast used in CCT and conventional angiography can cause contrast nephropathy these patients with will be excluded from the study
- •3. Recent history of alcohol, drug abuse, or other medical conditions that might compromise safety, successful completion of, or drug compliance during the study
- •4. Patients with a history of chronic inflammatory conditions, such as severe arthritis, lupus, or inflammatory bowel disease, as well as subjects taking immunosuppressant agents, such as cyclosporine, tacrolimus, azathioprine, or chronic oral glucocorticoids. Because High-Sensitivity C-Reactive Protein (hs-CRP) will be measured, patients with other conditions that may cause a chronically elevated CRP will be excluded.
- •5. Unstable angina pectoris
- •6. Uncontrolled fast atrial fibrillation or other arrhythmias that may interfere with ECG-gated triggering of CT
- •7. Patients with extreme tachycardia, greater than 110 bpm, despite rate controlling agents
- •8. Pregnancy
- •9. Morbid obesity (Body Mass Index [BMI] >35)
- •10. Known contrast medium allergy
- •11. Known ischaemic heart disease with previous intervention in the form of coronary artery bypass graft (CABG) or percutaneous coronary intervention (PCI)
- •12. Inability to lie flat.
- •13. Severe Aortic Stenosis (clinically suspected and confirmed by echocardiogram)
- •14. Acute myocarditis/pericarditis
- •15. Uncontrolled hypertension >220/100
- •16. Severe peripheral vascular disease or impaired immobility
- •17. Severe mental disability that would impair capacity to consent
- •18. Significant COPD that would impair exercise or B blocker use
- •19. Left bundle branch
研究者
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