A comparative study of intravenous ondensetron and palonosetron as pretreatment to prevent pain on injection of propofol
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Pain during injection of Propofol
研究概览
简要总结
Intravenous Propofol causes pain on injection, different drugs have been used to prevent Propofol injection pain 5HT3 receptor antagonist which are commonly used for prevention of nausea and vomiting are also used for having analgesic property. Different 5HT3 receptor antagonists were used as pretreatment in preventing this pain. In literature there are very minimal studies comparing Ondensetron and Palonosetron as pretreatment in preventing the Propofol injection pain.
The overall incidence of pain in group Ondensetron and group Palonosetron was 32% and 26% respectively. 4% of patient in group Ondensetron and 2% of patient in group Palonosetron complained of severe pain. Incidence of post operative nausea and vomiting in group Palonosetron (20%) was comparatively lower than group Ondensetron (38%).
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Posted for elective Laproscopic surgery under General anesthesia.
排除标准
- •Patients with presence of infection on the dorsum of non-dominant hand Patients with thin dorsal veins Patients with known hypersensitivity to Propofol, Ondensetron and Palonosetron.
结局指标
主要结局
Pain during injection of Propofol
时间窗: 1, 3 and 5 minute after induction
次要结局
- Post operative nausea and vomiting(Noted for 24 hours Post operative period)